The
first metal-catalyzed double aryl C(sp2)–H
bond activation of antipyrine and alkyne annulation reaction is reported.
This Ru(II)-catalyzed reaction was accomplished in the presence of
20 mol % phosphine ligand tricyclohexylphosphine tetrafluoroborate
to afford indolo[2,1-a]isoquinolines that are very
important compounds because of their bioactivity and interesting optical
properties.
An
unprecedented Pd(II)-catalyzed decarbonylative C–H/C–C
activation and annulation reaction, which proceeds via intramolecular
cyclization, is reported. This reaction of hydroxynaphthoquinones
with disubstituted alkynes provides good yields of substituted alkylidene
phthalides, which are the key intermediates for the synthesis of bioactive
natural products.
An efficient catalyst-free, one-pot multicomponent reaction has been developed for the synthesis of pyrimidine functionalized pyrrolo-annelated derivatives. The method offers easy and column free separation, mild reaction conditions and high yields.
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