Following our phytochemical studies of Costa Rican plants, we report the isolation of two new 3,4‐seco‐ent‐kaurenes from the aerial parts of Croton megistocarpus (Euphorbiaceae). The structures of the two compounds were elucidated as 14‐[(2‐methylbutanoyl)oxy]‐3,4‐seco‐ent‐kaura‐4(19),16‐dien‐3‐oic acid (1) and 14‐{[(2Z)‐2‐methylbut‐2‐enoyl]oxy}‐3,4‐seco‐ent‐kaura‐4(19),16‐dien‐3‐oic acid (2). In addition, seven known diterpene clerodanes were also isolated and identified. The structures of the compounds were elucidated by spectroscopic methods, including HR‐MS, 1H‐NMR, 13C‐NMR, COSY, HMQC, HMBC, and NOESY experiments.
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