Extramedullary plasmacytomas (EMP) are rare malignant plasma cell neoplasms (PCNs) mainly affecting the head and the neck region. These are more commonly seen in adult males. These have variable outcomes and may even coexist with, or progress to multiple myelomas (MMs). Hence, a systemic examination is a must, to rule out generalized involvement. The presence of monoclonal plasma cells on histopathology explains the relationship of PCNs with amyloidosis. Treatment may be surgical for accessible tumors or low to moderate dose radiation as indicated. Long-term surveillance is a must. We discuss two cases of extramedullary PCNs with amyloidosis involving the head-neck region. Both the patients underwent surgical excision followed by radiation for the residual disease and recurrence prevention. Systemic involvement was ruled out and the patients have been advised regular follow-up.
Introduction: Skeletal tuberculosis accounts for 1 to 3% of total cases of tuberculosis, out of which only 0.2 to 1.3% involve the calvarial bones, thus making it extremely rare.
Materials and methods:We discuss a case of tuberculous osteomyelitis of the frontal bone with orbital involvement. The patient was effectively managed by antituberculous therapy with no need for any surgical intervention.
Conclusion:With the advent of antituberculous chemotherapy and advanced diagnostic modalities, tuberculosis can be actively tackled, but still continues to be a leading public health problem in developing countries. A high index of suspicion in atypical cases must be considered.
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