Introduction:The risk of mortality for pediatric patients with severe chronic kidney disease (CKD) is 30fold higher than that for healthy patients of the same age. The main cause of death is cardiovascular disease (CVD), accounting for 25-50 % of deaths in children and young adults with childhood onset CKD. Aim of the study:To study serum hepcidin level and its role in anemia and cardiovascular dysfunction in children with CKD, either on hemodialysis (HD) or on conservative therapy. Methods: Serum samples were obtained from 20 healthy individuals and from 30 patients with CKD on regular dialysis (group I) and 20 patients with chronic kidney diseases on conservative therapy (group II).The levels of hemoglobin , serum ferritin, s. iron , TIBC, serum hepcidin, and echo parameters in form of fractional shortening (FS),l eft ventricular mass index (LVMI) and trans mitral to mitral annular early diastolic velocity ratio (E/Ea') ratio were determined and the correlation between them was studied. Results: There is a significant increase in the serum hepcidin levels in group I and group II than the control group. There was significant correlation between hepcidin and serum ferritin, s. iron, transferrin saturation, FS, LVMI, E/Ea' while there was a negative correlation between serum hepcidin and both hemoglobin and TIBC. Conclusion: Hepcidin level is a good biomarker for anemia and cardiac dysfunction in patients with chronic kidney disease.
Fractures of the proximal or distal thirds of the tibia are one of the most challenging injuries in orthopedic. A few strategies have been portrayed m the decision of procedure relies upon numerous elements including crack arrangement, bone quality, delicate tissue injury and accessible equipment.Intramedullary nailing might be powerful in dealing with these breaks even with straightforward articular augmentation, yet care should be taken with decrease and sufficient screws locking to forestall malalignment and ceaseless knee agony may likewise be an issue. This investigation included 20 patients with distal and proximal tibial breaks rewarded with intramedullary nail with multidirectional proximal and distal locking screws (Expert tibial nail). The time of follow up was up to 6months utilizing certain scoring frameworks. The suggestive and useful assessment results were reviewed by the models by Johner and Wruh's Criteria According to Johner and Wruh's measures, 45.0% of patients indicated great rules, 30.0% were brilliant, 15.0% were reasonable and just 10.0% were poor. Two cases created deferred association (10%), two cases built up Sudeck's decay (10%), one case created malunion (5%), one case created nonunion(5%) and foremost knee torment was found in four cases (20%). So front knee torment spoke to the most widely recognized intricacy in this study.Treatment of proximal and distal thirds tibial cracks utilizing master tibial intramedullary nail (with multidirectional locking screws) is a protected and acknowledged strategy option in contrast to customary nail and plating procedure. This structure of the embed helps in accomplishing stable obsession and improved securing most extraarticular tibial cracks.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.