According to current bibliography, uterine sarcomas represent a controversial entity among malignant lesions of female genital tract. Age of the patient, histologic type, grading and staging of the lesion, obesity, smoking and lymph vascular infiltration reflect as most important predisposition factors concerning ultimate therapeutic mapping, especially in women of reproductive age. After histologic establishment of lesion staging, multidisciplinary approach seems mandatory in order to discover postoperative pathways. Series of chemotherapy, radiotherapy or hormonal therapy consist corner stone of postoperative treatment in cases of advanced stages with depicted metastatic lesions. Aim of our study reflects assiduous presentation and depiction of pathophysiologic pathways of such lesions strongly accompanied with proper therapeutic strategy
Fibroids represent benign tumors consistingof smooth muscle cells and fibrous connective tissue. In most of cases, they develop inside the uterine cavity.It is estimated that 70-80% of women will develop fibroids in their lifetime-however, not everyone will develop symptoms or require treatment.Cause of uterine fibroids is not known, although studies demonstrate there may be a genetic component. There is no food or external exposure that a woman can have that can cause her to develop fibroids.
Ultimate goal remains fertility preservation, especially in young premenopausal patients.Laparoscopic approach represents proper surgical option depending on the age of the patient, the size and anatomic location of the uterine fibroids.
Scientific evaluation of current bibliography depicts the significance of prenatal diagnosis in terms of proper gestations surveillance.Appearance of such chromosomal anomalies is strongly accompanied with mother age, previous obstetrical or gynecologic history, previous surgical procedures.
Ultrasound depiction of Nuchal Translucency (NT) reflects the tendency of such gestations to develop such anomalies, influencing further pregnancy course.Final diagnosis, in cases of increased NT, consists Chorionic Villus Sampling (CVS) and further karyotype evaluation.
Among prenatal appearance of chromosomal anomalies, Trisomy 21 or Down syndrome represents the most common type with characteristic morphologic and clinical diagnosis.Prenatal diagnosis of dizygotic twins of opposite sex type with simultaneous appearance of Down Syndrome is very rare throughout current literature.Our study reflects presentation of such unique and rare case with proper diagnosis and treatment.
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