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Teaching is among the most emotionally demanding jobs, impacting teachers' personal lives and job performance. Since teaching-specific stressors are mainly socio-emotional related, social and emotional learning (SEL) interventions targeting teachers have increased rapidly in recent years. This study conducted a systematic review with meta-analysis of 43 empirical studies which evaluated the efficacy of school-based SEL interventions involving 3,004 in-service preK-12 teachers. The initial systematic review showed that these interventions were very heterogeneous and the research on their efficacy assessed widely distinct outcome variables. Concerning the meta-analysis, results showed statistically significant small to medium effect sizes favoring the experimental group, with SEL interventions impacting teachers' social and emotional competence [g = 0.59, 95% CI (0.29, 0.90)], well-being [g = 0.35, 95% CI (0.16, 0.54)], and psychological distress [g = −0.34, 95% CI (−0.57, −0.10)]. Meta-regressions did not reveal significant values of the explanatory variables, and publication bias was found for social and emotional competence and well-being domains. Findings add to growing empirical evidence regarding the impact of these interventions and contribute to the development of guidelines for the design of effective SEL interventions for teachers.

Objective. To independently replicate the top findings from 4 published genome-wide association studies (GWAS) of susceptibility genes in Behçet's disease (BD).Methods. We tested 14 single-nucleotide polymorphisms (SNPs) in 13 genomic loci (excluding the major histocompatibility complex [MHC], IL10, and IL23R-IL12RB2, which have already been associated with BD in Iranians) for allelic and genotypic associations with BD in 973 patients and 828 controls from Iran and performed meta-analyses of the significantly associated markers.Results. Six SNPs (in decreasing order of significance, rs7616215 located 38 kb downstream of CCR1, rs2617170 [p.Asn104Ser] in KLRC4, rs17810546 in IL12A-AS1, rs7574070 in STAT4, and rs10050860 [p.Asp575Asn] and rs13154629 in ERAP1) were nominally associated with BD in both allelic association tests (5.05 3 10 29 £ P allele £ 7.55 3 10 23 ) and sex-adjusted genotypic association tests (6.01 3 10 29 £ adjusted P value £ 1.30 3 10 22 ). For all 6 SNPs tested by meta-analysis (P meta ), the association with BD was strengthened, because the direction and magnitude of association were similar across populations (e.g., for rs7574070, odds ratio [OR] Conclusion. This study reinforces the notion that CCR1, KLRC4, IL12A-AS1, STAT4, and ERAP1 are bona fide susceptibility genes for BD, in addition to the MHC, IL10, and IL23R-IL12RB2 loci. Future genetic and functional studies are now warranted to uncover the roles of these genes in the pathogenesis of BD.Behçet's disease (BD) is a chronic multisystem vasculitis involving several organs, such as the skin, mucocutaneous membranes (oral and genital aphthae), eyes, joints, lungs, and the gastrointestinal and central nervous systems (1). Although the etiology and pathogenesis of BD remain unclear, the mechanism of BD is thought to be complex, with multiple genetic and environmental factors contributing to the clinical manifestations. Genome-wide association studies (GWAS) are currently the preferred method used to identify novel genetic risk variants, and the results of such studies have provided new insights into the biologic and genetic bases of many complex disorders. The use of association strategies at the whole-genome level led to the discovery of causal loci for numerous disorders.GWAS in patients with BD have been performed in Turkish, Japanese, Korean, Chinese, and Iranian populations (2-8). With the exception of the major histocompatibility complex (MHC), IL10, IL23R-IL12RB2, and STAT4 loci (3-6), these GWAS did not replicate the top findings of each other, which reinforces the need for well-powered independent replication studies in other populations to distinguish true universal association signals from population-specific associations. Therefore, we conducted a replication study of previous top GWAS Supported by the Portuguese Fundação para a Ciência e a Tecnologia (grants PTDC/SAU-GMG/098937

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