Background: Depressive disorder is one of the main health problems worldwide. Many risk factors have been associated with this pathology. However, while the association between risks factors and adult depression is well established, the mechanisms behind its impact remains poorly understood. A possible, yet untested explanation is the mediating impact of levels of personality functioning, i.e., impairments with regard to self and interpersonal.Method: Around 162 patients were assessed at the beginning of their therapy, with regard to risk factors, such as sociodemographic, physical, hereditary (Information Form), and adverse childhood experiences (ACE; CTQ). Depressive symptoms (Beck Depression Inventory, BDI) and personality functioning (OPD-SQ) were also measured. Associations between the related variables as well as other possible covariates were examined by means of zero-order correlations and bootstrapping-based mediation analysis.Results: Of all the risk factors taken into account, level of education and physical illness were associated with depression. On the other hand, the most significant predictor of depressive symptomatology was ACE, and this relationship was mediated by personality functioning. This indicates that patients presenting adverse childhood experiences are more likely to develop deficiencies in personality functioning, which in turn increases their likelihood of developing depressive symptomatology.Conclusion: These results reaffirm the importance of incorporating risk and vulnerability factors such as personality functioning in understanding depression.

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Cooperative home range defense is common in primates, despite a collective action problem that arises when group members benefit from winning the intergroup encounter regardless of whether they participate. The costs associated with this collective action problem may be mitigated by residing in small groups, residing with kin, or by forming strong bonds with group members. The potential to decouple the effects of these variables provided an opportunity to investigate which of these three variables best explains coparticipation in intergroup encounters among adult and subadult female colobus at Boabeng-Fiema, Ghana. Because males are often the main participants, we also investigated the relationship between female-female coparticipation and adult and subadult male participation. We collected intergroup behaviors from 94 adult and subadult individuals in eight groups during 1 year. We quantified female grooming bond strength and approach rates using focal samples.We classified female dyads as close kin (i.e., halfsiblings or more closely related) or nonkin based on partial pedigrees and genotypes generated from 17 STR loci. Female-female coparticipation was higher in dyads with stronger grooming bonds but was not associated with dyadic kinship, approach rate, or age class. Female coparticipation decreased with increasing female group size as expected if there is a collective action problem. Females coparticipated less in groups with more males and male intergroup aggression, possibly because there is less need for female-female cooperation if males are participating in the intergroup encounter.Females in smaller groups may not only benefit from increased female-female cooperation during intergroup encounters, they are also likely to reside with a higherquality alpha male, both of which may increase the likelihood of winning intergroup encounters. There may be strong selection for facultative female dispersal in populations like the Boabeng-Fiema colobus in which small groups are associated with multiple benefits and cooperation is not affected by kinship.

Background: Although several treatments are currently available for chronic pelvic pain, 30–60% of patients do not respond to them. Therefore, these therapeutic options require a better understanding of the mechanisms underlying endometriosis-induced pain. This study focuses on pain management after failure of conventional therapy. Methods: We reviewed clinical data from 46 patients with endometriosis and chronic pelvic pain unresponsive to conventional therapies at Puerta de Hierro University Hospital Madrid, Spain from 2018 to 2021. Demographic data, clinical and exploratory findings, treatment received, and outcomes were collected. Results: Median age was 41.5 years, and median pain intensity was VAS: 7.8/10. Nociceptive pain and neuropathic pain were identified in 98% and 70% of patients, respectively. The most common symptom was abdominal pain (78.2%) followed by pain with sexual intercourse (65.2%), rectal pain (52.1%), and urologic pain (36.9%). A total of 43% of patients responded to treatment with neuromodulators. Combined therapies for myofascial pain syndrome, as well as treatment of visceral pain with inferior or superior hypogastric plexus blocks, proved to be very beneficial. S3 pulsed radiofrequency (PRF) plus inferior hypogastric plexus block or botulinum toxin enabled us to prolong response time by more than 3.5 months. Conclusion: Treatment of the unresponsive patient should be interdisciplinary. Depending on the history and exploratory findings, therapy should preferably be combined with neuromodulators, myofascial pain therapies, and S3 PRF plus inferior hypogastric plexus blockade.

Aims: The establishment of normal values for the hamstring flexibility and isometric posterior thigh force of healthy adults performing standard motor task consisting of acting against a rubber band in the supine position. Study Design: Observation and ecological. Place and Duration of Study: During a Sports Medicine three days event (Congreso DePunta) in Uruguay, September 2018. Methodology: Random samples of 21 men and 16 women practicing different sport activities were asked to have their biomechanics properties measured by DINABANG, which is a novel clinical instrument to guide lower limb rehabilitation. DINABANG measures the force signal during the following specific motor task: in supine position, consists of hip flexion with fully extended knee and with malleolus attached to a rubber band held by the Physical Therapist behind the head of the person, until further effort would lift the person from the mat. Results: Normal values for body weight specific peak force during isometric effort with extended limb in supine position and malleolus strap tied to an elastic band are (mean ± SD) 1.7 ± 0.4 / 1.9 ± 0.5 N•Kg-1 for men and 2.1 ± 0.5 / 2.3 ± 0.5 N•Kg-1 for women and weak/strong limb respectively. The volunteer-defined flexibility angles of the healthy young populations (21 men and 16 women) were found to be 67.5° ± 6.5° and 77.5°± 9.7° merging the distributions of both lower limbs, strong and weak. Conclusion: These values will be included in subsequent versions of DINABANG to be used in clinical practice to help avoiding muscle strains by quantifying efforts during rehabilitation under Physical Therapist monitoring. DINABANG allows to safely perform a motor task in the medical office. It can be said that DINABANG is compatible with an ecological approach to rehabilitation.