Background: Aloe Vera, a medicinal herb, has been used for centuries in therapeutics and cosmetology. Objective: To compare Antiobesity effects of Aloe Vera whole leaf with new antidiabetic drug, Sitagliptin on streptozotcin induced diabetic rats. Study Design: Randomized Control Trial. Settings: Department of Pharmacology, Islamic International Medical College, Rawalpindi in collaboration with NIH, Islamabad, Pakistan. Duration: One year from September 2019 to August 2020. Methodology: Young Sprague Dawley rats, n=40, weighing 220-250 grams were taken and randomly divided into Groups A and B. Group B was fed on high fat diet for two weeks to develop insulin resistance. After induction of diabetes, with low dose streptozotocin, Group B was subdivided into: GroupB1 (Diabetic Control), Group B2 (Aloe Vera whole Leaf treated), Group B3 (Sitagliptin treated). Body weight was measured in all rats every week to assess progress of study, and finally on completion of study (on Day 60). SPSS version 25 was applied for statistical analysis. One-way ANOVA test was used for assessing any difference in the mean values. Post-hoc Turkey analysis was done to compare inter-group mean differences. P value of <0.05 was considered significant. Results: Mean body weight of Group A was 235.50g, Group B1 272.00g, B2 249.90g and B3 248.70g respectively. Rats in each of Group B2 and Group B3 had significant reduction in body weight compared to Group B1, with no statistically significant intergroup differences in results of Group B2 and B3. Conclusion: Aloe Vera whole leaf extract significantly decreased body weight with almost similar efficacy to Sitagliptin in diabetic rats.
Introduction: Aloe Vera, a perennial herb, is being used since ancient times for the cure of various diseases and is recently being used in curing diabetes due to the synergistic activity of its over 75 biologically active ingredients. The objective of the study was to compare the antidiabetic effects of Aloe Vera whole leaf extract with standard antidiabetic drug Sitagliptin on streptozotocin-induced diabetic rats. Material and Methods: The present study was RCT, conducted at the Department of Pharmacology, Islamic International Medical College, Rawalpindi in collaboration with the National Institute of Health, Islamabad, Pakistan, from September 2019 to August 2020. A total of 40, young Sprague Dawley rats weighing between 220-250 grams were taken and randomly divided into Group A (Normal Control) and group B. After induction of Type-2 Diabetes, group B was further subdivided into 3 groups with 10 rats each: Group B1 (Diabetic Control), Group B2 (Aloe Vera whole Leaf Extract treated), GROUP B3 (Sitagliptin treated). Terminal Sampling was done to measure FBS and HbA1c on Day 60. Statistical Analysis was done by applying SPSS version 25. A one-way ANOVA test was used for assessing any difference in the mean values. Post-hoc Turkey analysis was conducted to compare any inter-group mean differences. P-value of <0.05 was considered significant. Results: On completion of the study, at Day 60, mean FBS values for Rats in Group A were 82.40 mg/dl, for Group B1 498.40 mg/dl, for Group B2 89.30 mg/dl, and Group B3 93.00 mg/dl respectively. Mean HbA1c results for rats after terminal sampling in Group A were 3.71%, Group B1 11.84%, Group B2 4.02%, B3 3.73%. Rats in each of Group B2 (Aloe Vera whole leaf treated) and Group B3 (Sitagliptin treated) had a significant reduction in fasting blood sugar and HbA1c levels in comparison to Group B1 (diabetic control), with no statistically significant intergroup differences in results of Group A, Group B2 and Group B3. Conclusion: Aloe Vera whole leaf extract significantly decreased fasting blood glucose and HbA1c levels with almost similar efficacy to Sitagliptin in diabetic rats.
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