In this research, the 80S bioactive glass with different Ca/P ratios was prepared by the sol-gel route. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and Fourier transforms infrared spectroscopy (FTIR) were used to study the apatite structure and shape. According to the results, the 78SiO2-17P2O5-5CaO bioglass showed a higher rate of crystalline hydroxyapatite (HA) on its surface in comparison with the other bioglasses. After 3 days of immersion in the SBF solution, spherical apatite was formed on the 78SiO2-17P2O5-5CaO surface, which demonstrated high bioactivity. A statistically significant promotion in proliferation and differentiation of G292 osteoblastic cells was also observed. Regarding its optimal cell viability and bioactivity, the 78SiO2-17P2O5-5CaO bioactive glass could be offered as a promising candidate for bone tissue applications.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.