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A survey was conducted and the occurrence of anthelmintic resistance in strongyles of cattle was detected. Ten herds of cattle in Shaki, Oyo state of Nigeria were studied. Larval Development Assay (LDA) was used as the test method. Four drugs were tested. Resistance to the four drugs were detected. Resistance to albendazole were detected in two herds and in one herd for febantel with LD 50 > 0.10 µgml-1. Resistance to levalmisole and morantel was detected in three and in two herds respectively with LD 50 >1.0µgml-1