So-Chon Gil scite author profile

Background: Recent GWA studies have demonstrated an association between the endocytic clathrin adaptor PICALM and Alzheimer disease. Results: Manipulation of PICALM expression selectively alters APP endocytosis and A␤ production in neural cells and plaque deposition in APP transgenic mice. Conclusion: PICALM is involved in intracellular APP processing and plaque pathogenesis. Significance: Understanding cellular mechanisms involved in APP processing may reveal novel targets for intervention.

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So-Chon Gil

Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis

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