In addition to large domains, many short motifs mediate functional post-translational modification of proteins as well as protein-protein interactions and protein trafficking functions. We have constructed a motif database comprising 312 unique motifs and a web-based tool for identifying motifs in proteins. Functional motifs predicted by MnM can be ranked by several approaches, and we validated these scores by analyzing thousands of confirmed examples and by confirming prediction of previously unidentified 14-3-3 motifs in EFF-1.
BackgroundOxytocin is the gold standard drug for the prevention of postpartum haemorrhage, but limitations in cold chain systems in resource-constrained settings can severely compromise the quality of oxytocin product available in these environments. This study investigated the perspectives and practices of stakeholders in low and lower-middle income countries towards oxytocin, its storage requirements and associated barriers, and the quality of product available.MethodsQualitative inquiries were undertaken in Ethiopia, India and Myanmar, where data was collected through Focus Group Discussions (FGDs) and In-Depth Interviews (IDIs). A total of 12 FGDs and 106 IDIs were conducted with 158 healthcare providers (pharmacists, midwives, nurses, doctors and obstetricians) and 40 key informants (supply chain experts, program managers and policy-makers). Direct observations of oxytocin storage practices and cold chain resources were conducted at 51 healthcare facilities. Verbatim transcripts of FGDs and IDIs were translated to English and analysed according to a thematic content analysis framework.FindingsStakeholder awareness of oxytocin heat sensitivity and the requirement for cold storage of the drug was widespread in Ethiopia but more limited in Myanmar and India. A consistent finding across all study regions was the significant barriers to maintaining a consistent cold chain, with the lack of refrigeration facilities and unreliability of electricity cited as major challenges. Perceptions of compromised oxytocin quality were expressed by some stakeholders in each country.ConclusionKnowledge of the heat sensitivity of oxytocin and the potential impacts of inconsistent cold storage on product quality is not widespread amongst healthcare providers, policy makers and supply chain experts in Myanmar, Ethiopia and India. Targeted training and advocacy messages are warranted to emphasise the importance of cold storage to maintain oxytocin quality.
SUMMARYThis paper reports on an ongoing research project aimed at designing and deploying a Common Object Resource Broker Architecture (CORBA) (ww.omg.org) Commodity Grid (CoG) Kit. The overall goal of this project is to enable the development of advanced Grid applications while adhering to state-of-the-art software engineering practices and reusing the existing Grid infrastructure. As part of this activity, we are investigating how CORBA can be used to support the development of Grid applications. In this paper, we outline the design of a CORBA CoG Kit that will provide a software development framework for building a CORBA 'Grid domain'. We also present our experiences in developing a prototype CORBA CoG Kit that supports the development and deployment of CORBA applications on the Grid by providing them access to the Grid services provided by the Globus Toolkit.
Grid computing is the framework of computer systems that provides high performance computing environment. The challenging issue in grid computing is to design efficient and reliable task scheduling algorithms for efficient utilization of grid computing. In this paper, we are proposing a new Improvised Prioritized Deadline (IPD) based scheduling algorithm for efficient task execution with deadline constraints of users' tasks. The proposed algorithm considers the processing power of the resources while scheduling the tasks. Performance comparison of the algorithm has been done with the other task scheduling algorithms such as Earliest Deadline First (EDF) and Prioritized Based Deadline Scheduling Algorithm (PDSA). The proposed algorithm improves 45%-70% with respect to the average tardiness over the PDSA algorithm. The proposed algorithm also shows good results with respect to the number of non-delayed tasks. In the cases the purposed improvised algorithm has shown good results.
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