Uniform silver nanoparticles have been prepared through the chemical reduction of silver ions by ethanol in presence of sodium linoleate. TEM micrograph shows a uniform distribution of the particles with an average size of 12 nm. Further, the antimicrobial activity of silver nanoparticles shows that these nanoparticles can be used as effective growth inhibitors against Staphylococcus Basillus, Staphylloccoccus Aureus, and Pseudimonas Aureginosa

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TNF-α which is probably unable to bind with the surface receptor in testicular macrophages as because of altered structural morphology with reduction of cell function, render the animals more prone to infection and ultimately causes subfertility.

Objective: Owing to a possible relationship between hyperuricemia and coronary artery disease (CAD), the study was conducted to know the prevalence of hyperuricemia and its relation with the severity and prognosis of CAD. A total of 81 Methods: CAD patients of age group 36-83 years were divided in four groups based on serum uric acid (SUA) levels. The prevalence and severity of CAD were assessed by coronary angiography and New York Heart Association (NYHA) scales and their association with SUA level was statistically analyzed. The mean Results: age of patients was found to be 54.62±11.03 years. Increasing trends for mean SUA were found across the quartile (P<0.000). With increasing SUA levels, the mean value of Body Mass Index (BMI), Systolic Blood Pressure (SBP), and Diastolic Blood Pressure (DBP) also increased signicantly (P<0.01), (P<0.042) and (P<0.019) respectively. Mean SUA signicantly increased with NYHA class and the Multivessel disease (MV) showed a signicant increase (p<0.051) in CAD patients following the increase in SUA levels. The study extends further to support previous Conclusion: ndings and draws a link between different levels of SUA and CAD in this intriguing region of the country

Objective: Reports on the inverse relation between onset-to-door (OTD) and door-to-needle (DTN) in stroke thrombolysis have been repeatedly reported. The current study aimed to explore the association between DTN with the outcome and multi-component interventions inuencing DTN to understand better why some patients get IVT in >60 mins DTN time. Methods: Twenty-ve consecutive AIS patients treated with rt-PA in the Department of Neurology from January 2019 to December 2022 admitted to our tertiary care hospital were included in this analysis. The patients were grouped into a delay group (door-to-needle time (DTN) > 60 minutes; n=11) or a non-delay group (DTN time< 60 minutes; n= 14). The baseline data, laboratory tests, onset-to-door (OTD) time, door-to-imaging time (DTI), and decision-making time in both groups were retrieved. Multivariate logistic analysis was performed to analyze the data. Results: There were signicant differences in hypertension, coronary artery disease, admission National Institutes of Health Stroke Scale (NIHSS), the Door to Imaging (DCT), Door to Needle (DTN), and decision-making time (DMT) between the two groups (all P<0.05). Multivariate logistic regression analysis revealed that the in-hospital delay was closely related to mRS score, OTD time, DCTtime, DMT, and hypertension (p<0.001). Conclusion:The study reects that the lesser the door-to-needle time and the sooner the treatment of thrombolysis to stroke patients, the better the clinical outcomes and recovery of the patients

Spinal nerve root tumors can arise throughout the spine and at multiple levels, likely representing plexiform neurofibromas that grow from the nerve root into the intraspinal space either intradurally or epidurally and exit through the neural foramen, producing a dumbbell-shaped appearance. Although many cases of dumbbell-shaped extramedullary neurofibromas in the cervical spine have been reported, to the best of our knowledge, there are no reports of trident-shaped extramedullary neurofibromas. A 26-year-old woman presented with swelling over the right side of her neck. Diagnostic workup included magnetic resonance imaging (MRI) and contrast-enhanced computed tomography (CECT) of the neck, which revealed an intradural, extramedullary tumor mass at the right C2–C6 level with an extraspinal extension. Spinal cord compression or canal compromise is the most reliable indication for surgery. The solitary cervical neurofibroma was treated surgically in a single stage through laminoplasty and excision of the intradural tumor along with that of the neck component. This was performed without any complications. A single-stage double approach was adopted in this case. After total excision, the shape of the tumor was found to be more like a trident than a dumbbell. Hence, here we would like to suggest a new nomenclature for this neurofibroma, the trident neurofibroma.

Objectives: Thyroid dysfunction adversely affects myocardial contractility & relaxation, heart rate & cardiac output, which may nally lead to heart failure (HF). The purpose of the study was to determine the prevalence and type of thyroid dysfunction in ambulatory HF patients. Methods: Medical records of 138 patients diagnosed with HF based on Framingham's criteria enrolled at the cardiology outpatient department of our hospital were evaluated retrospectively. Demographic, risk factor, clinical and echocardiographic proles of the patients were statistically analyzed according to their thyroid status. Patients were grouped into subclinical hypothyroidism, hypothyroidism, low T3 syndrome, subclinical hyperthyroidism, and hyperthyroidism. The mean age of the patients was 64.7 ± 12.4 yrs. M Results: ale/female ratio was 2.1:1. Thyroid dysfunction was found in 39 % (n = 54) of the patients and 61 % (n = 84) patients had normal thyroid function. Most common type of thyroid dysfunction was low T3 syndrome which was found in 18.8 % (n = 26) patients; followed by subclinical hypothyroidism in 10.9 % (n = 15), hypothyroidism in 5.1 % (n = 7), subclinical hyperthyroidism in 2.1 % (n = 3), hyperthyroidism in 2.1 % (n = 3). Majority of patients (81.8 %, n = 113) were in NYHA class I & II. Hypertension was the predominant risk factor in both groups of patients with or without thyroid dysfunction (46.3 %; n = 25 and 42.8 %; n = 36). There was a high prevalence of HFrEF (72.2 %; n = 39) in patients with thyroid disorders compared to those with euthyroidism (34.5 %; n = 29). Signicant number of ambulatory HF patients has Conclusion: thyroid dysfunction. Early detection and treatment of thyroid dysfunction in HF patients will slow the progression of HF and improve the prognosis