A facile and high yielding synthesis of porphyrin appended thiazoles 5 from the reaction of 5-(4-thiocarboxamidophenyl)-10,15,20-triphenylporphyrin with a-bromo ketones has been described. The fluorescence studies of synthesized porphyrin appended thiazoles 5 in chloroform indicate that porphyrin p system is not greatly perturbed by substitution of a thiazole moiety at meso-phenyl ring even in the excited state.
A nickel nanoparticle (NPs) catalyzed one-pot three component reaction of phthalhydrazide, dimedone and aryl aldehydes under solvent free conditions has been reported. The present approach offers the advantages of simple methodology, clean and mild reaction conditions, short reaction time, low environmental impact, high yield, and excellent purity. The synthesized compounds (2H-indazolo[2,1-b] phthalazine-trione) are found to be suitable candidates for efficient fluorogenic assays to monitor bio-chemical environments.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.