The behavioral toxlcologst uses the techmques of ammal behavior to study the selectlve tomcity of neuropolsons [ 11. Ruffin [ 2 ) proposed the use of functional testrng in experimental ennronmentll torfcology r e l a h g to industrial health. Van Gelder [ 31 recently discussed the role of behavioral toxlcology m eluadating possible adverse health effects of environmental contammuis.Lead 19 a neurotoscant that 1s presently adversely affecting the health of humans and e s p e w d y children. As more c o m m m t l e s have become aware of the lead problem, rt has become apparent that lead toxicosls is not a problem limited to Lnner city areas [ 41.The epidemology of childhood leadpoisoning has been the subject of several r e n e w articles d w g the past years [ 5-91. That children in the 1to 5-year-old age group are prim;lrily involved ha3 been well estzblished The d source of lead 18 the consumption Protection Agency. tResearch funded by contract CPA 22-89-10?, Er.'ironmental405 CapyngIlht Q 1973 by M u c d Dr(dur. loc. All Righa R d . N e t l h s this work nor my pur n u y b. mpmduccd a ormmincd in any form or by any mum. e k a m r c or mech.nlul. tncludiq pkococopyin:. micmtilmin:. and mardin:. 01 by any inlonruuon n m g e and meal v8m. without pumrruon in wncing from the publisher. Clinical Toxicology Downloaded from informahealthcare.com by UB Wuerzburg on 11/01/14 For personal use only. Clinical Toxicology Downloaded from informahealthcare.com by UB Wuerzburg on 11/01/14 For personal use only. B. E. M e r , c. -k% J 'y -e r , J. Compar.%thoL, 60, 140 (1950). F. E. Rieke, Arch. Envzron. Health,79, 521 (1969). H. A. Scheffe, lometnice, 40, 87 ( 1953). ;md w. B. . Anal. Behavior, 15, 95 (1971). Buck, Clinical Toxicology Downloaded from informahealthcare.com by UB Wuerzburg on 11/01/14For personal use only.
Seven squirrel monkeys were systematically exposed to dieldrin (C12H10DC16) at two oral doses: 0.10 and 0.01 mg/kg-day. Two zero-dose controls were included. After 55 days of exposure dose assignments were shifted and continued for an additional 54 days. The higher dose group was shifted to zero exposure and lower dose group was shifted to high-dose exposure. Controls continued at zero exposure. The monkeys were presented with a visual nonspatial successive discrimination reversal task. During the first 55 days (preshift), control and low-dose monkeys learned the task; high-dose monkeys did not (p less than 0.001). During the subsequent 54 days (postshift), all groups performances remained at the approximate level achieved at the end of the preshift period. It was concluded that the high dose disrupted learning acquisition. This effect is speculated to be attributed to disruption of hippocampal activity. The low dose had no effect on task acquisition or maintenance.
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