Objective: The aim was to study of multiorgan dysfunction in patients with dengue and to correlate the severity and clinical outcome with different hematological parameters.Methods: All suspected cases of dengue admitted to medicine department within 1 year were evaluated and classified as dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). Results:Out of 150 cases, 108 cases were classified as DF, 31 cases as DHF and 11 cases as DSS. Liver involvement was seen in 97.33% of cases. Jaundice was observed in 10 cases (6.6%), abnormal aspartate transaminase in 146 (97.33%) cases, and abnormal alanine transaminase in 126 (84%) cases. Bleeding manifestations was reported in 61 patients (40.6%). The presence of gastrointestinal bleeding in 17 patients (11.3%) was related to severe disease. Thrombocytopenia was present in 25% of DF cases, and in all cases of DHF and DS. Among these, prothrombin time (PT) was prolonged in 10 cases and activated partial thromboplastin time (aPTT) in 47 patients. Serum fibrinogen was low in 28.57% of patients. Multiorgan dysfunction was observed in the form of simultaneous hepatic and renal dysfunction in 3.33% of cases, hepatic and central nervous system dysfunction in 2.66% of cases, hepatic and cardiac dysfunction in 2% of cases, and all the organ system dysfunction in 0.67% of cases. Conclusion:The extent of increase of liver enzymes, PT, aPTT and fall of serum fibrinogen, and degree of thrombocytopenia correlated with disease severity. Acute renal failure, encephalitis, and myocarditis are manifestations of severe form of dengue. Major organ involvement may occur in simple DF also.

Objective: to evaluate the incidence of cardiac arrhythmia in chronic cor pulmonale and to focus on the contributing etiological factors. Material & Methods: 35 cases of chronic cor pulmonale were thoroughly examined for the presence of arrhythmia. After recording history & physical examination blood was collected for various investigations like serum potassium, blood urea, blood volume and ABG study before and after the development of arrhythmia. Along with this X-ray & ECG were done in every case. Results: incidence of cardiac arrhythmia among all cor pulmonale patients was found to be 20% of which supraventricular ectopic beats was the most common. Respiratory infection may be thought to be the major factor in the development of congestive heart failure & different cardiac dysarrhythmia. Besides this, not a single possible factor has been found to be associated with cardiac arrhythmia. Conclusion: cor pulmonale has a low incidence in this part of country. Not a single factor associated with cardiac arrhythmia could be found out except pulmonary infection. Further studies are required in this field on a larger number of patients. DOI: http://dx.doi.org/10.3126/ajms.v5i1.8393   Asian Journal of Medical Science Vol.5(1) 2014 pp.15-19

Objective: Lupus nephritis (LN) is the most common and serious manifestation of systemic lupus erythematosus (SLE) and an important cause ofmorbidity and mortality. Although diagnosis of LN is straight forward in a patient with SLE and proteinuria, and active urine sediment and perhapsrenal insufficiency, still renal biopsies are required at diagnosis to enable classification of nephritis severity, to provide prognostic information, and toguide treatment. Hence, the objective of this study is to determine the frequency of distribution of different classes of LN based on renal biopsy reportsand to correlate it with various laboratory findings.Methods: Retrospective study was done in all patients with LN who had at least one representative renal biopsy and evaluated in NephrologyDepartment of SCB Medical College, Cuttack, in 6-month duration. Various laboratory values were recorded and correlated with histopathologicallupus classifications.Results: Out of 35 patients enrolled, 33 (94.28%) were females and 2 (5.71%) were males. Mean age was 27.53±12.26 years. Majority of cases belongto Class IV followed by Class V. Patients of Class IV LN have a significantly low hemoglobin level. Similarly, serum urea and creatinine are higher inGroup IV than other groups, and serum creatinine was found to be significant. 24 hrs urinary protein excretion has a significant correlation with theclasses of LN.Conclusion: This study suggests some meaningful correlation between laboratory findings and histopathological lupus classification. This study alsosuggests that renal biopsies are still beneficial for better evaluation of renal status and determination of LN classes.Keywords: Clinico-pathological correlation, Lupus nephritis, Biopsy.