Fibroepithelial lesions (FELs) are a heterogeneous group of tumours comprising fibroadenomas (FAs) and phyllodes tumours (PTs). Here we used a 16-gene panel that was previously discovered to be implicated in pathogenesis and progression, to characterise a large international cohort of FELs via targeted sequencing. The study comprised 303 (38%) FAs and 493 (62%) PTs which were contributed by the International Fibroepithelial Consortium. There were 659 (83%) Asian and 109 (14%) non-Asian FELs, while the ethnicity of the rest was unknown. Genetic aberrations were significantly associated with increasing grade of PTs, and were detected more in PTs than FAs for MED12, TERT promoter, RARA, FLNA, SETD2, TP53, RB1, EGFR, and IGF1R. Most borderline and malignant PTs possessed ≥ 2 mutations, while there were more cases of FAs with ≤ 1 mutation compared to PTs. FELs with MED12 mutations had significantly higher rates of TERT promoter, RARA, SETD2, EGFR, ERBB4, MAP3K1, and IGF1R aberrations. However, FELs with wild-type MED12 were more likely to express TP53 and PIK3CA mutations. There were no significant differences observed between the mutational profiles of recurrent FAs, FAs with a history of subsequent ipsilateral recurrence or contralateral occurrence, and FAs without a history of subsequent events. We identified recurrent mutations which were more frequent in PTs than FAs, with borderline and malignant PTs harbouring cancer driver gene and multiple mutations. This study affirms the role of a set of genes in FELs, including its potential utility in classification based on mutational profiles.Conflict of interest statement: PHT, BTT, and PT jointly hold patent applications for PCT/SG2015/050107 (Breast fibroadenoma susceptibility mutations and use thereof) and PCT/SG2015/050368 (Method and kit for pathologic grading of breast neoplasms). The other authors declare no competing interests.
A clinico-pathological study of tuberculosis in cervical lymph nodes was carried out among 30 cases irrespective of age and sex. Tuberculosis was common in adolescent and young adult life (63.3%). It was more prevalent in female (63.4%) and in poor socioeconomic condition (60%). Most of the cases were non-vaccinated (70%) and majority (70%) was tuberculin positive.
This is a case report of a middle aged man who presented with weight loss and epigastric pain. The initial diagnosis was space occupying lesion in liver. The mass was later demonstrated by trans-abdominal percutaneous needle biopsy to be an abscess caused by Ascaris lumbricoides. Fertilized Eggs and Larvae of Ascaris lumbricoides was found. Key Words: Liver Abscess; Ascaris Lumbricoides DOI: 10.3329/akmmcj.v1i2.7462 Anwer Khan Modern Medical College Journal 2010; 1(2): 25-26
With a view to cast a glance on pattern of non-thyroid neoplastic neck swelling a descriptive study was conducted among 54 cases irrespective of age and sex. It was observed that 85.2% non-thyroid neoplastic masses were malignant and of which 78.3% metastatic, and among them 80.6% were supraclavicular in origin. Among primary malignancy 90% were lymphomas and 37.5% of benign neoplasm were pleomorphic adenoma. Histopathologically 72.2% secondary tumours were squamous cell carcinoma.
Pneumatosis Cystoides Intestinalis is a rare condition characterised by gas-filled cysts in the wall of the smallgut and sometimes in its mesentry. When the process is limited to the large intestine, the term pneumatosis coli is used . The exact cause of the condition is unknown but it may develop in diseases like peptic ulcer, ulcerative colitis, regional enteritis, chronic bronchitis etc. The condition is usually diagnosed incidentally during abdominal scanning or investigation for the primary disease. Presentation as a case of gastric outlet obstruction (proximal jejunal obstruction) as happened in this case, is rare. A young adult male cultivator presented as a case of gastric outlet obstruction due to suspected chronic duodenal ulcer ( a common complication of Peptic ulcer disease in our country ). Per-operatively, gas filled cysts in proximal jejunum with almost obliteration of the lumen of the intestine was detected and diagnosed as a case of pneumatosis cystoides intestinalis and was treated with resection and anastomosis of the affected portion of gut. The patient is in good health even 5 years after the operation and showed no signs of recurrence of the condition. DOI: 10.3329/jbcps.v27i1.4243 J Bangladesh Coll Phys Surg 2009; 27: 45-48
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