In this study we evaluated the possible protective effects of selenium (Se) on hematological and oxidative stress parameters in rats chronically treated with cisplatin (cisPt). Four groups of Wistar albino rats were examined: a control, untreated rats (I), rats treated with Se (II), rats treated with cisPt (III), and rats treated with Se and cisPt (IV). All animals were treated for 5 days successively and killed 24 h after the last treatment. Hematological and oxidative stress parameters were followed in whole blood and red blood cells (RBC). Results showed that the chronic application of Se was followed by a higher number of reticulocytes and platelets, increased lipid peroxidation and GSH content in the RBC. Cisplatin treatment induced depletion of RBC and platelet numbers and an elevation of the superoxide anion, nitrites and glutathione levels. Se and cisPt co-treatment was followed by an elevation of the hematological parameters and the recovery of the glutathione status when compared to the control and cisPt-treated rats
Influence of the contact pressure in the deep drawing processes is a very actual research topic in the metal forming technology. Within this research the tribological model of the strip sliding in the flat die was developed. The original experimental computerized apparatus for testing of the strip sliding in the variable contact pressure conditions was developed, as well. The complex, multi-factor experiment was performed by application of the Al thin sheet, with the contact elements of various roughnesses, with different lubricants application and with the variable contact pressure. Besides the description of the developed apparatus, the theoretical way for determination of the pressure dependences was also presented. Based on the theoretical changes of pressure, set in advance, the real influence of the contact pressure was obtained, for each of the given conditions. That makes possible to determine the influence of the tribological factors on the actual pressure. The obtained real contact pressure has verified the reliability of the experimental apparatus, namely the degree of the theoretical pressure dependences deviation from the real ones.
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