The metabolism of testosterone administered to human subjects was studied soon after the isolation and synthesis of the testicular steroid hormone. In 1939, Dorfman, Cook, and Hamilton (1) and Callow (2) almost simultaneously reported the isolation of androsterone and etiocholanolone in the urine of men receiving testosterone propionate. During the 1940's, Lieberman, Dobriner and their co-workers (3-5) published extensive studies on steroids in human urine related to the metabolism of testosterone. West and his colleagues (6, 7) not only studied the urinary metabolites following the intravenous administration of testosterone (in human serum albumin), but in addition reported studies on the clearance from blood of testosterone and its metabolites (17-ketosteroids). All of the investigations cited were performed following the administration of very large, and hence unphysiological, doses of testosterone.It was not until methods were developed for the synthesis of labelled testosterone that it became possible to study the metabolism of the hormone administered in physiological doses. Gallagher, Fukushima, Dobriner and their associates were the first to report observations on the metabolism of C14 and deuterium labelled testosterone (8-11). The amounts of testosterone administered by these investigators approximated, in most cases, the quantity of hormone calculated to be excreted by the testes. Fukushima, Dobriner, Gallagher, and Bradlow (10,11) reported that the preponderant part of the administered labelled testosterone ap peared in the urine with small amounts in the feces. The authors did not report on the radioactivity in blood.The biliary excretion of steroids in human subjects has not been studied extensively. Such studies are of importance in the elucidation of testosterone metabolism in man, since it has been

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Plasma from male subjects with cancer of the prostate, who were receiving diethylstilbestrol treatment, was fractionated successively on columns of diethylaminoethylcellulose, Sephadex G-25, hydroxylapatite, and Sephadex G-75. Transcortin was detected

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