Ataxia Telangiectasia (AT) is a rare, neurodegenerative disease that affects many parts of the body and causes severe disability is characterized by progressive Cerebellar ataxia, oculocutaneous telangiectasia, and recurrent respiratory and sinus infections. AT is caused by a defect in the ATM gene, which is responsible for recognizing and correcting errors in duplicating DNA when cells divide, and in destroying the cells when the errors can not be corrected. A 10 years old girl who is the first issue of non consanguineous parents completely immunized according to EPI schedule was admitted to Dhaka Medical College Hospital, Dhaka, on 26.01.2010 with the complaints of generalized weakness and difficulty to walk from the 6th year. The patient has one younger sister of 7 years old who has such complaints. On examination the patient was found mildly anemic with congestions in both eyeballs that is radiating from the both corners to limbus. The patient was conscious and cooperative. Cranial nerves were intact. There were hypotonia which was more marked in lower limbs with diminished jerks and flexor plantar reflexes. Gait was wide based and ataxic. She was diagnosed as a case of AT. This case is presented as academic interest. Key words: Ataxia Telangiectasia (AT); neurodegenerative disease. DOI: 10.3329/jdmc.v19i1.6258 J Dhaka Med Coll. 2010; 19(1) : 69-71.
Background: Asthma is the most common chronic disorder in childhood. A high level of Ig E is associated with asthma. Objectives: The present study was carried out to observe the relation of serum IgE level with lung function parameters in asthma children and apparently healthy normal children. Methods: This study was carried out in the out patient department of paediatrics, Dhaka Medical College, Dhaka between January 2010 and June 2010. Total sixty children with age range from six to fifteen years of both sexes were included in this study. Thirty children suffering from asthma and thirty apparently healthy children with no systemic disorder were taken as study population. Serum Ig-E levels were measured in all subjects using a standard Immulite assay by ELISA method. Subjects were classified as having high IgE if their total IgE level was greater than or equal to 100 IU /ml .Subjects were classified as having low IgE if their total IgE level was less than 100 IU /ml. Spirometry was conducted on all patients by using Spirolab a new generation spirometer according to American Thoracic Society standards. Data were analyzed by unpaired t test and Chi-squares test. Results: The mean percentage of predicted values of FEV1, FVC, FEV1/FVC% were significantly lower in high Ig E (>100 IU/ml) level group in comparison with low Ig E(<100 IU/ml) group. Conclusion: Therefore the result of the present study reveals that higher IgE is related with lower lung function and also there were more chance in symptoms based asthma in our study populations. DOI: 10.3329/jdmc.v19i1.6242 J Dhaka Med Coll. 2010; 19(1) : 3-6.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.