Herein, we report an efficient synthesis of N-substituted pyrrole derivatives and their application to construct macrocyclic oxazocinone via a two-component coupling reaction followed by base mediated intramolecular cyclization. This methodology provides an easy two-step approach to constitute a library of fused pyrrolo-oxazocinone derivatives in good yields under mild reaction conditions. The present methodology offers an easy access to the synthesis of a library of fluorescent pyrole derivatives. Among them, tert-butyl 2-(2-(3-hydroxypropyl)-7-methoxy-4,5-dihydro-2H-benzo[e]isoindol-1-yl)acetate has been employed in bio-analytical imaging which shows efficient cellular internalization along with no obvious cellular toxicity.
Isoindolinones are the core structures of many natural products, drug molecules and it is useful in material science as fluorescent probe and synthetic dyes. Fused analogue of this blending lactam...
Pyrrole and their fused compounds are widely known as biologically active scaffolds and it mainly gets fused at 1-2 (a), 2-3 (b), 3-4 (c) or 4-5 (d) positions. In a...
Herein, we report one-pot Cu(I) catalyzed open flask synthetic strategy of 3-substituted N-pyridinyl isoindolinones from alkyl (E)-3-(2-formylphenyl)acrylate by oxidative amidation and intramolecular aza-Michael reaction using cheap air stable Cu(I) single catalyst. We have also established a synthetic route of Naryl substituted isoindolinones with acid-amine coupling reaction of (E)-2-(3-alkoxy-3-oxoprop-1-en-1-yl)benzoic acid followed by aza-Michael reactions. Unexpected synthetic route of N-(1H-inden-1-yl)pyridin-2-amine derivatives have been documented from the same precursors using Cu(I) catalyst.
Herein, we report a rare pentacyclic N‐fused hetrocycle synthesis via palladium catalyzed intramolecular C−H arylation along with the brief synthetic study of new type of bicyclic/tricyclic pyrrole rings. This pyrrole rings provided diversely substituted polycyclic nitrogen fused heterocycles from N‐benzyl/N‐benzyloxy pyrroles with good to excellent yields.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.