Objectives Blood vessels provide convenient conditions for tumor cell proliferation and distant metastasis. Antiangiogenesis and proapoptosis of tumor cells have become critical means of clinically treating tumors. This study aimed to investigate the antiangiogenic and pro-apoptotic abilities of α-solanine. Methods This study used the CCK8 method to select appropriate drug concentrations. Next, the antitumor mechanism of α-solanine under hypoxia was investigated using wound healing, transwell, cellular immune, and Western blot assays. Finally, a reverse validation was performed by adding MHY1485, an mammalian targets of rapamycin ( mTOR) activator. Results α-Solanine significantly decreased B-cell lymphoma2-related protein , n-Ca, vascular endothelial growth factor , MMP2, and MMP9 expression in cells. In addition , Bax, p53, TIMP1, and E-Ca expressions were upregulated. However, this study found that adding MHY1485 significantly attenuated the effects of α-solanine. These results suggest that α-solanine may achieve these functions by regulating the PI3K/Akt/mTOR signaling pathway. Conclusion α-Solanine is highly resistant to angiogenesis and promotes apoptosis of M2 tumor-associated macrophages. These effects may depend on the PI3K/Akt/mTOR signaling pathway. The present study demonstrated that α-solanine has a strong anticancer effect under hypoxic conditions.
Objective
To understand the related risk factors of occurrence and recurrence of hypertension and provide scientific basis for relevant departments to better guide prevention and control work.
Methods
From September 2017 to September 2018, a prospective follow‐up study was performed on patients with hypertension who visited the Second People's Hospital of Wuhu City, Anhui Province. Multivariate Cox regression was used to analyze influencing factors of stroke occurrence and recurrence in follow‐up of hypertensive patients.
Results
A total of 769 hypertensive patients were enrolled in this study. The average age of hypertensive patients was 65.66 ± 11.70 years old and the BMI index was 24.99 ± 4.17. In this study, 769 patients with hypertension were followed up for 1 year, and the incidence of stroke was 14.69%. This study found that higher levels of blood glucose (RR = 2.027, 95% CI: 1.195–3.438), HCY (RR = 5.928,95% CI: 1.438–24.440), aggravated extent of carotid artery stenosis (RR = 2.620, 95% CI: 1.532–4.481), and drinking (RR = 3.867, 95% CI: 2.038–7.339) were risk factors, and maintaining exercise (RR = 0.325, 95% CI: 0.117–0.907) was a protective factor for stroke occurrence; however, aggravated extent of carotid artery stenosis (RR = 3.158, 95% CI: 1.797–5.550) and smoking (RR = 2.271, 95% CI: 1.142–4.517) were risk factors for stroke recurrence for hypertensive patients.
Conclusions
For people with high blood pressure, it is necessary to exercise properly, control body weight, avoid obesity, quit smoking, reduce alcohol consumption, and reasonably control blood pressure, blood sugar, and blood lipid.
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