Background: Accurate preoperative prediction of cervical lymph node (LN) metastasis in patients with papillary thyroid carcinoma (PTC) provides a basis for surgical decision-making and the extent of tumor resection. This study aimed to develop and validate an ultrasound radiomics nomogram for the preoperative assessment of LN status. Methods: Data from 147 PTC patients at the Wuhan Tongji Hospital and 90 cases at the Hunan Provincial Tumor Hospital between January 2017 and September 2019 were included in our study. They were grouped as the training and external validation set. Radiomics features were extracted from shear-wave elastography (SWE) images and corresponding B-mode ultrasound (BMUS) images. Then, the minimum redundancy maximum relevance algorithm and the least absolute shrinkage and selection operator regression were used to select LN status-related features and construct the SWE and BMUS radiomics score (Rad-score). Multivariate logistic regression was performed using the two radiomics scores together with clinical data, and a nomogram was subsequently developed. The performance of the nomogram was assessed with respect to discrimination, calibration, and clinical usefulness in the training and external validation set. Results: Both the SWE and BMUS Rad-scores were significantly higher in patients with cervical LN metastasis. Multivariate analysis indicated that the SWE Rad-scores, multifocality, and ultrasound (US)-reported LN status were independent risk factors associated with LN status. The radiomics nomogram, which incorporated the three variables, showed good calibration and discrimination in the training set (area under the receiver operator characteristic curve [AUC] 0.851 [CI 0.791-0.912]) and the validation set (AUC 0.832 [CI 0.749-0.916]). The significantly improved net reclassification improvement and index-integrated discrimination improvement demonstrated that SWE radiomics signature was a very useful marker to predict the LN metastasis in PTC. Decision curve analysis indicated that the SWE radiomics nomogram was clinically useful. Furthermore, the nomogram also showed favorable discriminatory efficacy in the US-reported LN-negative (cN0) subgroup (AUC 0.812 [CI 0.745-0.860]). Conclusions: The presented radiomics nomogram, which is based on the SWE radiomics signature, shows a favorable predictive value for LN staging in patients with PTC.

In this work, WC-10Co-4Cr coatings were separately deposited on 300M steel by high-velocity oxygen fuel (HVOF) and high-velocity air fuel (HVAF) spraying processes. Microstructure, porosity, micro-hardness, bonding strength, wear and corrosion resistance of the coatings after different processing were investigated and compared. The result shows that dense and homogeneous microstructure existed in both two WC-10Co-4Cr coatings. Owing to lower temperature flames and higher particle velocity in the HVAF process, the HVAF-sprayed WC-10Co-4Cr coating exhibited less decarburisation, lower porosity (0.74%), higher micro-hardness (1162 HV 0.3 ) and bonding strength (74.68 MPa) than HVOF-sprayed WC-10Co-4Cr coating. In addition, wear and corrosion resistance of these two coatings were evaluated by sliding wear test and electrochemical corrosion test. The HVAF-sprayed WC-10Co-4Cr coating also exhibited excellent wear resistance and superior corrosion property than HVOF-sprayed WC-10Co-4Cr coating.

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The results presented suggest that miRNA for silencing SOD2 radiosensitizing gene therapy maybe applicable to the nasopharyngeal carcinoma, improving the therapeutic ratio of cancer radiotherapy.

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