Popular SSD-based key-value stores consume a large amount of DRAM in order to provide high-performance database operations. However, DRAM can be expensive for data center providers, especially given recent global supply shortages that have resulted in increasing DRAM costs. In this work, we design a key-value store, MyNVM, which leverages an NVM block device to reduce DRAM usage, and to reduce the total cost of ownership, while providing comparable latency and queries-per-second (QPS) as MyRocks on a server with a much larger amount of DRAM. Replacing DRAM with NVM introduces several challenges. In particular, NVM has limited read bandwidth, and it wears out quickly under a high write bandwidth. We design novel solutions to these challenges, including using small block sizes with a partitioned index, aligning blocks post-compression to reduce read bandwidth, utilizing dictionary compression, implementing an admission control policy for which objects get cached in NVM to control its durability, as well as replacing interrupts with a hybrid polling mechanism. We implemented MyNVM and measured its performance in Facebook's production environment. Our implementation reduces the size of the DRAM cache from 96 GB to 16 GB, and incurs a negligible impact on latency and queries-per-second compared to MyRocks. Finally, to the best of our knowledge, this is the first study on the usage of NVM devices in a commercial data center environment.

This article is an eight-year retrospective on development priorities for RocksDB, a key-value store developed at Facebook that targets large-scale distributed systems and that is optimized for Solid State Drives (SSDs). We describe how the priorities evolved over time as a result of hardware trends and extensive experiences running RocksDB at scale in production at a number of organizations: from optimizing write amplification, to space amplification, to CPU utilization. We describe lessons from running large-scale applications, including that resource allocation needs to be managed across different RocksDB instances, that data formats need to remain backward- and forward-compatible to allow incremental software rollouts, and that appropriate support for database replication and backups are needed. Lessons from failure handling taught us that data corruption errors needed to be detected earlier and that data integrity protection mechanisms are needed at every layer of the system. We describe improvements to the key-value interface. We describe a number of efforts that in retrospect proved to be misguided. Finally, we describe a number of open problems that could benefit from future research.

Telomeres protect chromosome ends from inappropriately activating the DNA damage and repair responses. Primary microcephaly is a key clinical feature of several human telomere disorder syndromes, but how microcephaly is linked to dysfunctional telomeres is not known. Here, we show that the microcephalin 1/BRCT-repeats inhibitor of hTERT (MCPH1/BRIT1) protein, mutated in primary microcephaly, specifically interacts with the TRFH domain of the telomere binding protein TRF2. The crystal structure of the MCPH1–TRF2 complex reveals that this interaction is mediated by the MCPH1 330YRLSP334 motif. TRF2-dependent recruitment of MCPH1 promotes localization of DNA damage factors and homology directed repair of dysfunctional telomeres lacking POT1-TPP1. Additionally, MCPH1 is involved in the replication stress response, promoting telomere replication fork progression and restart of stalled telomere replication forks. Our work uncovers a previously unrecognized role for MCPH1 in promoting telomere replication, providing evidence that telomere replication defects may contribute to the onset of microcephaly.

Facebook uses MySQL to manage tens of petabytes of data in its main database named the User Database (UDB). UDB serves social activities such as likes, comments, and shares. In the past, Facebook used InnoDB, a B+Tree based storage engine as the backend. The challenge was to find an index structure using less space and write amplification [1]. LSM-tree [2] has the potential to greatly improve these two bottlenecks. RocksDB, an LSM tree-based key/value store was already widely used in variety of applications but had a very low-level key-value interface. To overcome these limitations, MyRocks, a new MySQL storage engine, was built on top of RocksDB by adding relational capabilities. With MyRocks, using the RocksDB API, significant efficiency gains were achieved while still benefiting from all the MySQL features and tools. The transition was mostly transparent to client applications. Facebook completed the UDB migration from InnoDB to MyRocks in 2017. Since then, ongoing improvements in production operations, and additional enhancements to MySQL, MyRocks, and RocksDB, provided even greater efficiency wins. MyRocks also reduced the instance size by 62.3% for UDB data sets and performed fewer I/O operations than InnoDB. Finally, MyRocks consumed less CPU time for serving the same production traffic workload. These gains enabled us to reduce the number of database servers in UDB to less than half, saving significant resources. In this paper, we describe our journey to build and run an OLTP LSM-tree SQL database at scale. We also discuss the features we implemented to keep pace with UDB workloads, what made migrations easier, and what operational and software development challenges we faced during the two years of running MyRocks in production. Among the new features we introduced in RocksDB were transactional support, bulk loading, and prefix bloom filters, all are available for the benefit of all RocksDB users.

Penile metastasis of prostate cancer is rare, with a poor prognosis, and only a limited number of relevant cases have been reported so far. With the application of 18F-PSMA-1007 PET/CT, the biochemical recurrence of prostate cancer can be detected at an early stage for providing important evidence, facilitating clinical decision-making. Here, we have reported a case of solitary penile metastatic recurrence in the context of mild PSA progression (PSA: 0.072 ng/ml). This case highlights the preferable sensitivity of 18F-PSMA-1007 PET/CT imaging in prostate cancer.

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PurposeThis study aimed to assess the value of 18F-PSMA-1007 positron emission tomography/computed tomography (PET/CT)-derived semi-quantitative parameters of primary tumor for risk stratification of newly diagnosed prostate cancer (PCa).MethodsSixty patients referred for 18F-PSMA-1007 PET/CT imaging for primary PCa were retrospectively analyzed and classified into the low-intermediate-risk (LIR) or high-risk (HR) group. The maximum standardized uptake value (SUVmax) of primary tumor, prostate total lesion PSMA (TL-PSMAp), and prostate PSMA-tumor volume (PSMA-TVp) were measured, and group differences were evaluated using the Mann–Whitney U test. Spearman’s correlation was performed to assess the correlation between the above parameters with prostate-specific antigen (PSA) levels and Gleason score (GS). Receiver operating characteristic (ROC) curve analysis was used to determine optimal cut-off values for SUVmax, TL-PSMAp, and PSMA-TVp to identify high-risk PCa and compare diagnostic efficacy.ResultsAmong 60 patients, 46 were assigned to the HR group and 16 to the LIR group. In all patients, SUVmax, TL-PSMAp, and PSMA-TVp were moderately correlated with pre-treatment PSA values (r = 0.411, p = 0.001; r = 0.663, p < 0.001; and r = 0.549, p < 0.001, respectively). SUVmax and TL-PSMAp were moderately correlated with GS (r = 0.457 and r = 0.448, respectively; p < 0.001), while PSMA-TVp was weakly correlated with GS (r = 0.285, p = 0.027). In the ROC curve analysis, the optimal cut-off values of SUVmax, TL-PSMAp, and PSMA-TVp for identifying high-risk PCa were 9.61, 59.62, and 10.27, respectively, and the areas under the operating curve were 0.828, 0.901, and 0.809, respectively. The sensitivities of SUVmax, TL-PSMAp, and PSMA-TVp were 91.03%, 71.74%, and 63.04%, respectively, and the specificities were 71.43%, 100.00%, and 92.86%, respectively.ConclusionsTL-PSMAp had a superior ability to identify high-risk PCa. The semi-quantitative parameters of primary tumor on 18F-PSMA-1007 PET/CT imaging can be an objective imaging reference index to determine PCa risk stratification.