Medicinal plants are unique in having the ability to produce diverse chemical compounds with remarkable biological activities. Investigations of medicinal plants resulted in the discovery of a large number of bioactive compounds with excellent therapeutic properties. Solanum surattense, a perennial wild growing medicinal herb, is widely used in the traditional medicine. Exhaustive literature availability reveals the presence of phytochemical compounds from different plant parts like roots, stem, leaves, fruits, and seeds reported to possess a wide range of pharmacological activities like hepatoprotective, cardioprotective, antiasthmatic and mosquito repellents properties. Intensive investigation on phytochemical constituents resulted in isolation of alkaloid and steroidal compounds solasonoine, solamargine, campesterol, and diosgenin. Evaluation of therapeutic activity of isolated compounds proved as potent ones with reference to the standard. Current literature on the pharmacological activity of S. surattense confirms the scientific validation of folklore claims and its traditional use to cure various ailments. Present review is undertaken to summarize all the available information on pharmacological activities, which provide a baseline support for further exploration of its unexplored therapeutic effects like immunomodulation, antipiles activity, antianaphylactic activity, and sexual behavior claimed by folklore.