The target of the study was the development and in vitro characterisation of an effective ethosomal formulation of clotrimazole and to the performance of the formulation was investigated under different preparation conditions. The EE and from 9 formulations, the optimisation was done on the basis of its results which considering the concentration of lecithin and ethanol as the two factors and EE and in vitro release as their responses. The optimization was done on the basis of its results which considering the concentration of lecithin and ethanol as the two factors and EE and in vitro release as their responses. F6 formulation gained a very good release of drug and highest entrapment efficiency of 93.203%. The results of permeation flux were obtained in the order of MLVs > ESUVs > SSUVs > LUVs. This study gives an idea about the vesicles structure and the size, the technique used, the drug EE and the permeation rate. They were taking the above factors into consideration results in improving clinical effectiveness in transdermal delivery of an ethosomal formulation of clotrimazole.
Rosai Dorfman disease is a rare histiocytic disorder. It is also known as Sinus Histiocytosis. It is with massive lymphadenopathy involves an overproduction of a type of white blood cell. The disease is rarely associated with intracranial and intraorbital involvement. Intracranial Rosai-Dorfman can mimic meningioma. Other pathologies also underline its pathologies. Here, we report a nine-year-old boy with a history of proptosis of the right eye and presenting with multiple skull lesions. Histopathological study revealed Sphenopetroclival lesion, which features that of Rosai Dorfman Disease. His MRI scan of the brain was taken, which showed evidence of right optic nerve meningioma with sella and suprasellar extension, causing severe proptosis. The child underwent right frontotemporal craniotomy with petrosectomy and Transylvanian, subtemporal approach to multicompartmental Rosai-Dorfmans lesion. After four months, the patient had a recurrence of the disease on which chemotherapy and steroids were started, which also did not show much response while taking an MRI scan. A corticosteroid is a useful option in the Central Nervous System Rosai Dorfman disease treatment. But this patient showed a negative outcome to the treatment.
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