The primary objective of this study was to evaluate insulin sensitivity in healthy subjects treated with olanzapine or risperidone. Subjects were randomly assigned to single-blind therapy with olanzapine (10 mg/d), risperidone (4 mg/d), or placebo for approximately 3 wk. Insulin sensitivity was assessed pre- and posttreatment using a 2-step, hyperinsulinemic, euglycemic clamp. Glucose and insulin responses were also assessed by a mixed meal tolerance test. Of the 64 subjects randomized, 22, 14, and 19 in the olanzapine, risperidone, and placebo groups, respectively, completed the study procedures. There were no significant within-group changes in the glucose disposal rate or the insulin sensitivity index for the active therapy groups. Further, the results of the mixed meal tolerance test did not demonstrate clinically significant changes in integrated glucose metabolism during treatment with these medications. In summary, this study did not demonstrate significant changes in insulin sensitivity in healthy subjects after 3 wk of treatment with olanzapine or risperidone.
D iabetic Mellitus (DM) is a lifelong chronic disease that has a major impact on health care costs. Taking care of diabetic patients relies heavily on adequate and accurate informatics. In order for care providers to view a patient history and to be able to project the trend of future treatments, the health information system must be concise and include a function for easy access to patient records to efficiently locate all the related data. At the Bangkok Medical Center (BMC), the existing Hospital Information System (HIS) is mainly used to manage administrative functions, such as making appointments, registering patients, order entry, results reporting, and billing. The traditional paper clinical record from providers are still used and scanned as an image into the HIS. We found that the HIS is too generalized and broad, and does not meet the specific needs for diabetes management. The display of information is sub-optimal, not only because it's incomplete and often contains scanned images of illegibly written notes, but also because it presents a cluttered user interface (UI) that includes myriad windows with laboratory results, radiology reports and medication lists, making viewing of summarized data quite difficult.Additionally, The American Diabetes Association's (ADA) standards of medical care in Diabetes 2014 1 suggested that optimal diabetes management requires an organized, systematic approach with the involvement of a coordinated team of dedicated health care professionals working in an environment where patient-centered high-quality care is a priority. Furthermore, the provision of care coordination as recommended by ADA and Joint Commission International (JCI), can only be achieved by leveraging information system technology. 2,3 We looked for a tool to compliment and extend our HIS to deliver diabetes-specific care.We ultimately decided to innovate and develop a new diseasespecific electronic medical record (EMR) system to support the management of diabetes patients. Hopefully, this project will encourage other specialists to use this disease-specific EMR instead of traditional clinical records stored on paper.In summary, the expected goals of the project are as follows:-To create a system of choice for endocrinologists and other physicians to use interactively, allowing them to focus on the medical history rather than resorting to paper for clinical notes and orders. -To improve both function and workflow for effective management and care of DM Type 2 patients. -To achieve and sustain the standard medical care recommended by JCI and ADA. -To ensure effective communication between a multidisciplinary care team. -To reduce the use of paper and enable a fully digital clinical record of care.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.