In order to explore the relationship between drug grafting ratio of polymeric prodrug and its drug loading efficiency, molecular dynamics simulation is utilized to calculate the compatibility of polymeric prodrug with 5‐aminolevulinic acid methyl ester (m‐ALA) and H2O first. Then, dissipative particle dynamics simulation is used to observe the morphologies of drug‐loaded micelles. Then, designed polymeric prodrugs are synthesized, drug‐loaded micelles and blank micelles are prepared by dialysis method, and the drug loading content (DLC) and encapsulation efficiency are measured. The computer simulation shows that polymer–drug compatibility gets better as the m‐ALA grafting ratio increases from 0% to 100%. Experimental results show that the DLC of micelle changes from 4.05% (0% grafting ratio) to 8.99% (100% grafting ratio). Through comparison, the experimental results are proven to be consistent with the computer simulation results, revealing that the drug loading efficiency of polymer micelles could be improved by grafting drugs.
Democracy is considered by many to be the ultimate form of government. This paper tries to identify the effects of choosing certain regime types over others on the economic development of that society. Through careful review of several scholars’ works on this topic, this study finds that several key factors, such as how long has the newly created democracy existed, how well democratic institutions are established (free and fair elections, control over economy, rule of law etc.). Simply transitioning into a democracy does not guarantee economic growth, but maturing as a democracy does. This study seeks to provide a meaningful discussion and help its audience understand the more specific details of each type of regime, thus allowing for a closer examination of the debate of democracy versus autocracy. Through this paper, readers will be able to understand what makes a mature democracy, and how does a mature democracy help economic development.
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