With the development of smart devices and information technology, it is possible for users to optimize their usage of electrical equipment through the home energy management system (HEMS). To solve the problems of daily optimal scheduling and emergency demand response (DR) in an uncertain environment, this paper provides an opportunity constraint programming model for the random variables contained in the constraint conditions. Considering the probability distribution of the random variables, a home energy management method for DR based on chance-constrained programming is proposed. Different confidence levels are set to reflect the influence mechanism of random variables on constraint conditions. An improved particle swarm optimization algorithm is used to solve the problem. Finally, the demand response characteristics in daily and emergency situations are analyzed by simulation examples, and the effectiveness of the method is verified.
eIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNA-selective functions of individual subunits remain poorly defined. Using multi-omic profiling upon acute depletion of eIF3 subunits, we observed that while eIF3a, b, e, and f markedly differed in their impact on eIF3 holo-complex formation and translation, they were each required for cancer cell proliferation and tumor growth. Remarkably, eIF3k showed the opposite pattern with depletion promoting global translation, cell proliferation, tumor growth, and stress resistance through repressing the synthesis of ribosomal proteins, especially RPS15A. Whereas ectopic expression of RPS15A mimicked the anabolic effects of eIF3k depletion, disruption of eIF3 binding to the 5'-UTR of RSP15A mRNA negated them. Supported by mathematical modeling, our data uncovers eIF3k-l as a mRNA-specific module which, through controlling RPS15A translation, serves as a rheostat of ribosome content to secure spare translational capacity that can be mobilized during stress.
Various countries in the world are vigorously developing energy-saving industries and attaching importance to the improvement of household energy efficiency, but it is difficult to evaluate user power consumption characteristics due to insufficient information and large data granularity. It is, however, possible to evaluate the energy efficiency of household users via non-intrusive load monitoring (NILM). This paper explores the energy efficiency assessment of residential users and proposes a household energy efficiency assessment method based on NILM data. An energy efficiency assessment index of residents is provided by analyzing factors that affect residents’ energy efficiency. This index is clear, operable, and easy to obtain and quantify. Based on NILM information, clustering, and comprehensive evaluation, as well as combining the entropy weight method with the Technique for Order Preference by Similarity to an Ideal Solution (TOPSIS), a user’s energy efficiency can be evaluated and analyzed. Some case studies are provided to verify the validity of the proposed method based on non-intrusive information, to analyze the characteristics and deficiencies of the user’s energy consumption, and to give corresponding energy recommendations.
eIF3, whose subunits are frequently overexpressed in cancer, regulates mRNA translation from initiation to termination, but mRNAselective functions of individual subunits remain poorly defined. Using multiomic profiling upon acute depletion of eIF3 subunits, we observed that while eIF3a, b, e, and f markedly differed in their impact on eIF3 holo-complex formation and translation, they were each required for cancer cell proliferation and tumor growth. Remarkably, eIF3k showed the opposite pattern with depletion promoting global translation, cell proliferation, tumor growth, and stress resistance through repressing the synthesis of ribosomal proteins, especially RPS15A. Whereas ectopic expression of RPS15A mimicked the anabolic effects of eIF3k depletion, disruption of eIF3 binding to the 5 0 -UTR of RSP15A mRNA negated them. eIF3k and eIF3l are selectively downregulated in response to endoplasmic reticulum and oxidative stress. Supported by mathematical modeling, our data uncover eIF3k-l as a mRNA-specific module which, through controlling RPS15A translation, serves as a rheostat of ribosome content, possibly to secure spare translational capacity that can be mobilized during stress.
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