Herein
a simple, catalyst- and solvent-free system for highly atom-economic
synthesis of phthalazinones has been developed using phthalaldehydic
acid, 2-acyl-benzoic acid, and substituted hydrazine as simple substrates.
The reaction time was shortened to 20–60 min. Structurally
diverse phthalaldehydic acids, 2-acyl-benzoic acids, and hydrazines
were transformed into phthalazinones with a nearly 100% yield regardless
of the aggregate state and electronic nature of the substituents.
The transformation was demonstrated to be amenable for scale-up with
multiple liquid and solid materials. In addition, isolation and purification
of the crude products can be simply done with only crystallization.
The heavy metal pollution was also eliminated from the source.
A novel dual-site fluorescent probe (CTPA) was rationally designed and synthesized for the detection of hypochlorite (ClO-) and polarity. CTPA displayed an excellent sensitivity (LOD = 11.9 nM) and selectivity...
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