nes. -17 Title compounds of type (V) are prepared and most of them show moderate to good antimycobacterial activity. Compound (Ve) exhibits maximum potency and is more active than the standard drug pyrimethamine. The X-ray structure of (Vb) is given. -(PONNUCHAMY, S.; KANCHITHALAIVAN, S.; RANJITH KUMAR*, R.; ASHRAF ALI, M.; SOO CHOON, T.; Bioorg. Med. Chem. Lett. 24 (2014) 4, 1089-1093, http://dx.doi.org/10.1016/j.bmcl.2014.01.007 ; Dep. Org. Chem., Madurai Kamaraj Univ., Madurai 625 021,Tamil Nadu, India; Eng.) -M. Bohle 31-134
In the title compound, C22H18FNO3S2, the five-membered thiazolidine ring is planar (r.m.s. deviation = 0.003 Å) and forms dihedral angles of 70.2 (3), 73.16 (17) and 10.32 (14)° with the cyclopropane, fluorobenzene and methylthiobenzene rings, respectively. The sum of the bond angles around the thiazolidine ring N atom (359.6°) indicates sp
2 hybridization. The molecular structure features intramolecular C—H⋯S, C—H⋯F and C—H⋯O interactions. In the crystal, no significant intermolecular contacts were apparent.
Twenty three substituted pyridylpyridones were designed and performed for molecular docking studies against α-amylase enzyme. The top three hit molecules were synthesized and characterized by 1H NMR, 13C NMR, ESI-mass and FT-IR spectroscopic techniques. Experimental biological applications were studied for these compounds. The DFT calculations were executed for the hit compounds. In addition, molecular electrostatic potential mapping was also executed for additional support.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.