Invasive lobular carcinoma (ILC) of the breast exhibits unusual clinicopathological, radiological, histological, and metastatic patterns. We present here two cases of ILC of the breast that presented with an unusual pattern of metastasis involving the uterus.Our first patient presented to her primary gynaecologist with profuse vaginal bleeding and underwent total abdominal hysterectomy and bilateral salpingo-oophrectomy. She had fibroadenoma excised from her left breast four years previously. Histopathology revealed lobular carcinoma diffusely infiltrating uterus, cervix, and bilateral ovaries. Retrospective examination of the left breast showed induration along the previous fibroadenoma excision scar. A biopsy from the scar suggested lobular carcinoma.Our second patient presented with a hard indurated cervix mass that mimicked primary cervix carcinoma. She had ILC of the right breast four years previously for which she underwent mastectomy followed by adjuvant chemotherapy and radiotherapy. She was on tamoxifen. Further evaluation at presentation with imaging showed extensive intra-abdominal disease involving peritoneum with moderate ascites, adnexal masses, and confluent para-aortic nodal mass. A cervix biopsy confirmed metastasis from lobular carcinoma.Metastatic involvement of the genital tract should be considered in women with a history of breast cancer who present with abnormal vaginal bleeding, suspicious pelvic examination, or radiological findings. We suggest such patient be vigorously screened with biopsy even if the patient is disease-free for several years. It is crucial to differentiate the metastasis from primary carcinoma of the genital tract as there are vast differences in the management of each.
Dental composites used in conservative and orthodontic dentistry are based on bisphenol A-glycidyl methacrylate (BIS-GMA) resin. However, certain limitations, such as high viscosity and handling difficulties, restrict the use of BIS-GMA and attempts have been made to modify the resin or to seek alternate materials. The synthesis and characterization of a urethane tetramethacrylate resin (UTMA) is reported here, which when reinforced with a silanated radiopaque glass filler, is found to provide composite pastes with superior properties. Composite pastes with formulations of varying BIS-GMA/UTMA blend ratios have been prepared and their effect on the compressive strength, diametral tensile strength, transverse strength, Vickers microhardness, water sorption, and opacity have been studied. The photoinitiator concentration has been varied for 100% urethane-based composite and its optimum concentration standardized.
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