Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical...
An efficient continuous flow process for the synthesis
of dolutegravir,
an active pharmaceutical ingredient (API) for HIV treatment, was investigated.
The synthetic procedure starts from a readily available benzyl-protected
pyran via six chemical transformations using continuous flow reactors.
The significant advantage of this flow process includes the reduction
of the overall reaction time from 34.5 h in batch to 14.5 min. The
overall yield of each reaction step improved dramatically upon flow
optimization. Another key feature of this synthesis is telescoping
multiple steps.
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