Abstract. In cattle, squamous cell carcinomas (SCC) are the most frequent malignant tumors. Where the animals most affected are those that have depigmentation in the mucocutaneous region. This study aimed to report the clinical case of suspected third eyelid squamous cell carcinoma in a Holstein cow. Clinical care was carried out on a female bovine, of the Dutch breed of approximately 5 years of age, in the anamnesis, the owner reported that six months ago there had been an increase in volume on the side of the animal's left eye. Upon general clinical examination, no changes in physiological parameters were detected. On specific eye examination, it was found in the left eye that the third eyelid had a bulky mass, with mucopurulent secretion. The treatment performed in this service was through surgery to remove this eye mass, suspected of squamous cell carcinoma. Where the tumor was removed with the maximum safety margin possible so that it would not return again. After topically applied to the affected eye, antibiotic and associated anti-inflammatory, Terra-Cortril® Spray (oxytetracycline hydrochloride and hydrocortisone), for 7 days / BID. In this case, the suspicion of SCC in the third eyelid is concluded through anamnesis and macroscopic lesions visualized on clinical examination. The treatment was surgical excision, but histopathological analysis was not performed, being of total importance for obtaining a conclusive diagnosis. Thus, it is concluded that the follow-up of the case after treatment is extremely important, due to the assessment of the clinical condition.
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