Exercise and physical activity have proven benefits for physical and psychological well-being. However, it is not clear if healthy young adults can enhance mood in everyday life through regular exercise. Earlier studies mainly showed positive effects of acute exercise and exercise programs on psychological well-being in children, older people and in clinical populations. Few studies controlled participants' physical activity in daily life, performed besides the exercise program, which can impact results. In addition the transition from mood enhancement induced by acute exercise to medium or long-term effects due to regular exercise is not yet determined. The purpose of this pilot study was to examine the acute effects of an aerobic running training on mood and trends in medium term changes of mood in everyday life of young adults. We conducted a 10-week aerobic endurance training with frequent mood assessments and continuous activity monitoring. 23 apprentices, separated into experimental and control group, were monitored over 12 weeks. To control the effectiveness of the aerobic exercise program, participants completed a progressive treadmill test pre and post the intervention period. The three basic mood dimensions energetic arousal, valence and calmness were assessed via electronic diaries. Participants had to rate their mood state frequently on 3 days a week at five times of measurement within 12 weeks. Participants' physical activity was assessed with accelerometers. All mood dimensions increased immediately after acute endurance exercise but results were not significant. The highest acute mood change could be observed in valence (p = 0.07; η2 = 0.27). However, no medium term effects in mood states could be observed after a few weeks of endurance training. Future studies should focus on the interaction between acute and medium term effects of exercise training on mood. The decreasing compliance over the course of the study requires the development of strategies to maintain compliance over longer periods.

Over the last few years, the estimation of energy expenditure with accelerometers has become more and more accurate due to improvements in sensor technology. Significant enhancement could be reached by model-based estimation regarding different activity types. The kmsMove-sensor (movisens GmbH, Karlsruhe, Germany) is a device that is used to compute human energy expenditure using motiondependent calculation models. It is outfitted with an accelerometer to measure body acceleration during certain movements and activities. To validate its accuracy, the sensor was compared to indirect calorimetry as criterion measure. For this experiment, nine subjects (all males, age 46.4±10.9 years, 28-64 years) were equipped with the kmsMove-sensor as well as a portable indirect calorimeter and their energy consumption was measured over a time period of 100 min. Additionally, the energy consumption of seven out of the above-mentioned nine subjects was measured over an average of 7 h. The measurements took place in a rehabilitation clinic, where the subjects completed their regular daily rehabilitation activities. An analysis of the data revealed ICCs between the kmsMovesensor and indirect calorimetry for the time period of 100 min of 0.82 (0.38-0.96; p=0.003) and for an averaged measuring time of 7 h of 0.81 (0.22-0.97; p=0.01). Furthermore, a Bland-Altman analysis for the time period of 100 min led to a difference of the means of 4.3 kcal (limits of agreement: −94.3 and 102.9 kcal) and for the time period of an average of 7 h to −14.0 kcal (limits of agreement: −320.0 and 292.0 kcal). These findings indicate that the kmsMovesensor is an appropriate measuring device with relatively good accuracy to assess human energy expenditure in rehabilitation patients. However, this study has some limiting aspects (small sample size, artificial setting) which could influence validity.

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Certain subsets of the population are especially sensitive to carcinogens, and this can be determined using molecular biological methods. In the literature there has been evidence presented for the use of p21ras (ras) as a tumor marker for human carcinogenic substances such as asbestos, polycyclic aromatic hydrocarbons, and vinyl chloride in the workplace. In this study we have examined whether serum ras could serve as a biomarker for the early detection of occupationally derived lung cancer, with an emphasis on Schneeberger (radon-induced) lung cancer. Sera were taken from 65 male tumor patients. Fifty-nine patients suffered from primary lung cancer (including 18 patients with Schneeberger lung cancer and 12 patients with asbestos-related lung cancer). Additionally, 29 patients with non-malignant lung disease, and a healthy control group (44) including 32 former uranium miners of SDAG Wismut exposed to ionizing radiation (radon and its decay products) were examined. Ras protein was determined via three different methods: 1) immunoprecipitation followed by SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting; 2) SDS-PAGE using 5-17% gradient gels followed by Western blotting; 3) pre-incubation with Blue Sepharose, SDS-PAGE on 5-17% gradient gels, and Western blotting. The results show that 1 ng ras protein was measurable in serum standards. This protein could not be detected in patient sera or in sera from any of the study groups. Thus, ras cannot be considered useful as a marker for the early detection of asbestos-induced or Schneeberger lung cancer.