Objective To evaluate the long‐term outcome and efficacy of intravitreal injection of gentamicin and dexamethasone sodium phosphate (IVGD) or triamcinolone in end‐stage glaucoma patients and determine pre‐procedure prognostic indicators of success and post‐operative complications. Procedure Medical records were reviewed for 108 dogs (108 eyes) treated with intravitreal gentamicin with or without dexamethasone sodium phosphate or triamcinolone for glaucoma between 2013 and 2018 with 3 months of minimum follow‐up. Signalment and clinical findings, including type of glaucoma, pre‐procedure intraocular pressure (IOP), chronicity, procedure protocol, and outcome were recorded. Success was defined as an intraocular pressure of ≤25 mm Hg at the time of last re‐examination or no ocular hypotensive medications at 3 months or longer post‐injection. Results The overall success rate for pharmacologic ablation was 95%. The success rate for dogs receiving no ocular hypotensive medications was 86%. Seventy‐six eyes (70.4%) had primary glaucoma, and 32 eyes (29.6%) had secondary glaucoma. Age at the time of injection had no effect on initial success but did in final success (P =‐.03) for dogs requiring repeat injections. Cocker Spaniels required the most repeat 2nd and 3rd injections (3/12 dogs) and (2/4 dogs), respectively. No preoperative variable significantly affected the success rate. The most common complications were phthisis bulbi (59.2%), corneal edema (25.9%), and ulcerative keratitis (22.3%). Uncontrolled IOP resulted in enucleation in two dogs (1.8%). Conclusions Pharmacologic ablation has a high overall success rate in lowering IOP to ≤25 mm Hg short‐term in blind, glaucomatous canine eyes. Type of glaucoma, pre‐procedure IOP, chronicity, and protocol did not affect success.

Objective To describe the clinical presentation and outcome of canine patients that present with lipid‐laden aqueous humor (LLA) and to evaluate its association with other ocular and systemic disorders. Methods Medical records were identified and reviewed of 30 dogs presenting with clinical signs of LLA between 2013 and 2017 and compared to the canine referral population during the same time period. The percentage of dogs affected by LLA and potential risk factors were compared between groups. Results There were 40 eyes in 30 dogs with LLA out of 8011 (0.4%) referrals. The mean age of dogs with LLA was significantly younger than dogs without LLA (P = .0334). Sex was not associated with LLA. Miniature Schnauzers were more likely to have LLA than mixed breeds (P < .0001). Incidence of LLA was significantly higher in eyes also affected by corneal ulceration (P = .0018) or phacoemulsification (P = .0001). Sixty‐two percent and 51% of dogs with LLA had concurrent diabetes mellitus and hypertriglyceridemia, respectively. Average triglyceride level of dogs with LLA was 1087 mg/dL (±544) (reference 50‐150 mg/dL) and average cholesterol level was 575 mg/dL (±232) (reference 125‐300 mg/dL). Complete resolution of LLA was achieved in all dogs re‐examined with an average of 20.2 days (range 4‐175 days) after diagnosis. There were 6/30 dogs lost to follow‐up. Recurrence of LLA occurred at least once in 4/24 dogs (16.7%) after resolution. Conclusions Lipid‐laden aqueous humor occurs more frequently in Miniature Schnauzers. Corneal ulceration and phacoemulsification are risk factors. Complete resolution was seen in all cases with a low incidence of recurrence.