A 9-year-old male neutered Cockerpoo dog was presented with pyrexia and was diagnosed with sterile idiopathic panniculitis. During initial investigations, advanced imaging revealed a suspected left-sided cervical paraganglioma and bilateral adrenal masses. The dog underwent immunosuppression and achieved remission of the sterile idiopathic panniculitis. Bilateral adrenalectomy and paraganglioma excision were then performed. Histopathology identified bilateral adrenocortical carcinoma and cervical neuroendocrine carcinoma. Three months later, the dog was diagnosed with primary hyperparathyroidism. Despite left total thyroidectomy and parathyroidectomy, mild hypercalcaemia persisted for several months. Eight months later the dog became persistently hypokalaemic refractory to potassium supplementation, with metabolic alkalosis and systemic hypertension. The dog was euthanised 5 months later due to clinical deterioration. On postmortem examination, right parathyroid hyperplasia and metastatic neuroendocrine carcinoma involving liver, jejunum, pancreas and tracheobronchial lymph node were identified. This is the first report describing the concurrent presence of these types of endocrine neoplasms in a dog.
Case records of two dogs diagnosed with carotid body tumour (CBT) treated with radiotherapy were reviewed. Clinical signs of a unilateral space‐occupying lesion were identified. Cytology or histopathology and CT imaging confirmed CBT. Metastatic lymphadenopathy was identified in one dog. The tumour was surgically unresectable in one dog. Radiotherapy was administered with 38Gy in 10 and 48Gy in 12 fractions, respectively. VRTOG grade I cutaneous radiotoxicity was recognised in both dogs upon completing the treatment protocol. One dog was diagnosed with primary hypothyroidism 16 months later. One dog has ongoing partial response at 13 months post‐radiotherapy, the other dog had complete response with no recurrence at 40 months post‐radiotherapy. The results of this study suggest that for non‐resectable carotid body paraganglioma radiation therapy provided excellent disease control with mild permanent side effects not affecting the dog's quality of life. Careful monitoring of the thyroid function is recommended post‐treatment.
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