Our results imply that besides type of antidementia agent, involvement of a specialist in the complex process of prescribing antidementia drugs can provide meaningful benefits to patients, in terms of more disease-specific and continuous treatment.

It has been suggested that visual images are memorized across brief periods of time by vividly imagining them as if they still were there. Such visual imagery has been proposed as a key mechanism underlying working memory. However, the ability to evoke visual imagery varies substantially across individuals, raising the question whether people with weak or even absent visual imagery might use other, non-visual strategies for memorization. Here, we systematically investigated this question in two groups of participants, very strong and very weak imagers, that were asked to remember images across brief delay periods. We were able to reliably reconstruct the memorized stimuli from early visual cortex during the delay period. Importantly, the quality of reconstruction was equally accurate for both strong and weak imagers. The decodable information also closely reflected behavioral precision in both groups, suggesting it could potentially contribute to behavioral performance, even in the extreme case of completely aphantasic individuals. Our data thus suggest that strong and weak imagers do not differ in how early visual areas encode memory-related information and that this information might even be equally used in both groups.