Confusion frequently occurs in patients with gliomas for a number of reasons. One cause is a superimposed intracerebral infection. The case of a 73-year-old man who deteriorated after debulking of a high-grade glioma is described. However, he was successfully treated for Listeria monocytogenes (L. monocytogenes) diagnosed from blood cultures. This case highlights the importance for all health care workers to have a low threshold for diagnosing reversible causes of confusion in patients with gliomas - including this particularly rare cause, and not attributing their symptoms to the primary intracranial pathology.
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