Patients with neuropathic pain secondary to failed back surgery syndrome (FBSS) typically experience persistent pain, disability, and reduced quality of life. We hypothesised that spinal cord stimulation (SCS) is an effective therapy in addition to conventional medical management (CMM) in this patient population. We randomised 100 FBSS patients with predominant leg pain of neuropathic radicular origin to receive spinal cord stimulation plus conventional medical management (SCS group) or conventional medical management alone (CMM group) for at least 6 months. The primary outcome was the proportion of patients achieving 50% or more pain relief in the legs. Secondary outcomes were improvement in back and leg pain, health-related quality of life, functional capacity, use of pain medication and non-drug pain treatment, level of patient satisfaction, and incidence of complications and adverse effects. Crossover after the 6-months visit was permitted, and all patients were followed up to 1 year. In the intention-to-treat analysis at 6 months, 24 SCS patients (48%) and 4 CMM patients (9%) (p<0.001) achieved the primary outcome. Compared with the CMM group, the SCS group experienced improved leg and back pain relief, quality of life, and functional capacity, as well as greater treatment satisfaction (p

A serle• of semlaqueous HCI solutions of known concentration, containing 0.1 M KN03 (as Ionic strength adjuster) and 0-70 wt % methanol, was titrated at 21, 25, and 37 °C with standardized KOH, pH 2-12. The pH measuring circuit (Rosstype electrode) was calibrated with an aqueous pH buffer (Nernet slope assumed). The operational pH readings were related to peH (=log [H+]) by the four-parameter equation:The parameters were determined by a weighted nonlinear least squares procedure, which allows for C02 corrections. This calibration procedure was applied at 25 °C In titrations to determine the pK, values of acetic add, benzoic add, 4-n-butoxyphend, 4-ethoxyphend, 1-benzyWmkfazde, (± )-proprandd, and Af-methyl-o-gluc amine and of two water-insoluble highly lipophilic benzdc acid derivatives of pharmaceutical Interest, with the aim of determining their odanol-water partition coefficients. Ya-•uda-Shedlovsky plots were used to extrapolate semlaqueous apparent p/f,'s to zero methanol.

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At 24 months of SCS treatment, selected failed back surgery syndrome patients reported sustained pain relief, clinically important improvements in functional capacity and health-related quality of life, and satisfaction with treatment.