Around the world, lung cancer has long been the main factor in cancer-related deaths, with small-cell lung cancer (SCLC) being the deadliest form of lung cancer. Cancer cell-derived exosomes and exosomal miRNAs are considered promising biomarkers for diagnosing and prognosis of various diseases, including SCLC. Due to the rapidity of SCLC metastasis, early detection and diagnosis can offer better diagnosis and prognosis and therefore increase the patient’s chances of survival. Over the past several years, many methodologies have been developed for analyzing non-SCLC-derived exosomes. However, minimal advances have been made in SCLC-derived exosome analysis methodologies. This Review discusses the epidemiology and prominent biomarkers of SCLC. Followed by a discussion about the effective strategies for isolating and detecting SCLC-derived exosomes and exosomal miRNA, highlighting the critical challenges and limitations of current methodologies. Finally, an overview is provided detailing future perspectives for exosome-based SCLC research.

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On the occasion of the inauguration of the first gallery founded by artists in Tunis, the painters Moses Levy, Pierre Boucherle, Antonio Corpora and Jules Lellouche published in 1936 a manifesto affirming their autonomy, beyond mercantile logics and national assignments. However, a national reading of their works prevailed in the press, at that time. This article proposes to put this founding event of the « École de Tunis » into context, by reinscribing it in a century-old history. This past is marked by the presence of French and Italian artists between 1840 and 1880, by the failure of a policy of asserting a French artistic model with an aborted project for a French museum around 1890, and by the affirmation of an artistic life characterised since the 1910s by its pluralism and even its eclecticism. This article thus intends to contribute, through the example of pictorial production, to the historicisation of discourses on the plurality or cultural identity of Tunisia, which are still today objects of debate.