Antidepressant response occurred at a range of doses and at <0.5 mg/kg. The dose-titration approach is a practical method for optimizing the efficacy - side-effects trade-off on an individual patient basis. This pilot study provides preliminary evidence for SC injection as a practical, feasible and efficacious treatment approach.

The visual appearance of a Web page influences the way a user will interact with the page. Web page structural elements (such as text, tables, links, and images) and their characteristics (such as colour and size) are used to determine the visual presentation and complexity level of a Web page. We theorise that by understanding a user's visual and aesthetic perception of a Web page we can understand the cognitive effort required for interaction with that page. This paper describes an investigation into user perception of the visual complexity and aesthetic appearance of Web pages. Results show a strong and high correlation between users' perception of visual complexity, structural elements (links, images, words and sections) and aesthetic appearance (organisation, clearness, cleanliness, interestingness and beautifulness) of a Web page. We argue that the results should be used as a further understanding for keeping the balance between aesthetic appearance of a Web page and its visual complexity. Web pages will then be designed that can still be aesthetically attractive but also usable and not overloaded with information for the users.

This is the first trial to present dose-response data of ketamine efficacy and psychomimetic effects in depressed subjects. Antidepressant efficacy may be dose-related. Psychotomimetic effects were dose-related. Rapid infusion over 2 min may not be a feasible clinical approach to treatment, given poor tolerability.

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This paper proposes the inclusion of travel and mobility in the usability metrics of web design. Hypertext design and usability has traditionally concentrated upon navigation and/or orientation. The notion of travel extends navigation and orientation to include environment, mobility and the purpose of the travel task. The presence of travel aids are important for all users, but particularly so for those with a visual impairment. This paper presents the ground work for including travel into web design and usability metrics by presenting a framework for identifying travel objects and registering them as either cues to aid travel or obstacles that hinder travel for visually impaired users. The aim is to maximise cues and minimise obstacles to give high mobility as measured by the mobility index. This framework is based upon a model of real world travel by both sighted and visually impaired people, where travel objects are used for orientation, navigation, route planning and survey knowledge. Knowledge of the differences in travel between visually impaired and sighted people will enable the model to be used in assisting the design of better user agents and web content for visually impaired and other users.

The visual complexity of Web pages is much talked about; “complex Web pages are difficult to use,” but often regarded as a subjective decision by the user. This subjective decision is of limited use if we wish to understand the importance of visual complexity, what it means, and how it can be used. We theorize that by understanding a user's visual perception of Web page complexity, we can understand the cognitive effort required for interaction with that page. This is important because by using an easily identifiable measure, such as visual complexity, as an implicit marker of cognitive load, we can design Web pages which are easier to interact with. We have devised an initial empirical experiment, using card sorting and triadic elicitation, to test our theories and assumptions, and have built an initial baseline sequence of 20 Web pages along with a library of qualitative and anecdotal feedback. Using this library, we define visual complexity, ergo perceived interaction complexity, and by taking these pages as “prototypes” and ranking them into a sequence of complexity, we are able to group them into: simple, neutral, and complex. This means we can now work toward a definition of visual complexity as an implicit measure of cognitive load.

The equality of access – accessibility – is difficult to quantify, define, or agree upon. Our previous work analysed the responses of web accessibility specialists in regard to a number of pre-defined definitions of accessibility. While uncovering much, this analysis did not allow us to quantify the communities’ understanding of the relationship accessibility has with other domains and assess how the community scopes accessibility. In this case, we asked over 300 people, with an interest in accessibility, to answer 33 questions surrounding the relationship between accessibility, user experience (UX), and usability; inclusion and exclusion; and evaluation, in an attempt to harmonise our understanding of web accessibility. We found that respondents think that accessibility and usability are highly related and also think that accessibility is applicable to everyone and not just people with disabilities. Respondents strongly agree that accessibility must be grounded on user-centred practices and that accessibility evaluation is more than just inspecting source code; however, they are divided as to whether training in ‘Web Content Accessibility Guidelines’ is necessary or not to assess accessibility. These perceptions are important for usability and UX professionals, developers of automated evaluation tools, and those practitioners running website evaluations

The QUIJOTE (Q-U-I JOint Tenerife) CMB Experiment will operate at the Teide Observatory with the aim of characterizing the polarisation of the CMB and other processes of Galactic and extragalactic emission in the frequency range of 10-40 GHz and at large and medium angular scales. The first of the two QUIJOTE telescopes and the first multi-frequency (10-30 GHz) instrument are already built and have been tested in the laboratory. QUIJOTE-CMB will be a valuable complement at low frequencies for the Planck mission, and will have the required sensitivity to detect a primordial gravitational-wave component if the tensor-to-scalar ratio is larger than r = 0.05.