A neutropenic patient with acute myeloid leukaemia experienced a breakthrough infection of Trichosporon asahii during posaconazole treatment. After treatment was changed to a combination therapy with voriconazole and liposomal amphotericin B, the infection resolved. Posaconazole works effectively as an antifungal prophylaxis and salvage therapy in rare invasive fungal infections. This case however illustrates that breakthrough infections with T. asahii may occur during posaconazole treatment.
Purpose
There continues to be a disparity in the representation of women across medicine, including in editor positions at major medical journals. The authors repeated a study they had conducted in 2011 to compare the representation of women in editor-in-chief and editorial board member positions in 2011 and 2021.
Method
The authors included in their analysis the 60 journals from their original 2011 study and the top 5 ranked journals by Journal Impact Factor in each of 12 disciplines in 2021. This led to the inclusion of 86 journals. The authors collected the names and genders of the editors-in-chief and editorial board members at these journals, using information provided by the journals and a Google search for the photos and/or pronouns of the remaining editors. They compared results across years (2021 vs 2011), editor positions, disciplines, Journal Impact Factors, and ranks.
Results
Twenty-two of the 90 editors-in-chief (24.4%) were women in 2021 compared with 10 of 63 (15.9%) in 2011, an increase of 8.5%. Of the 6,285 editorial board members, 1,756 were women (27.9%) in 2021 compared with 719 of 4,112 (17.5%) in 2011, an increase of 10.4%. Journals with women editors-in-chief gained 3.5 ranks and 9.1 points in Journal Impact Factor on average over this 10-year period, compared with no gain in rank and an increase of 4.7 points in Journal Impact Factor for journals with men editors-in-chief; both are statistically significant differences (
P
= .045 and
P
= .016, respectively).
Conclusions
In almost all evaluated disciplines and editor positions, there was an increase in the percentage of women at top-ranked medical journals over a 10-year period. Despite this increase, improvements are still needed to accelerate the currently slow rate of change in these positions to enhance diversity, equity, and inclusion for women in medicine.
Objective: Chronic hypoparathyroidism (HP) is associated with acute and chronic complications, especially those related to hypocalcemia. We aimed to analyze details on hospital admissions and the reported deaths in affected patients.
Design and methods: In a retrospective analysis, we reviewed the medical history of 198 patients diagnosed with chronic HP over a continuous period of up to 17 years at the Medical University Graz.
Results: The mean age in our mostly female cohort (70.2%) was 62.6 18.7 years. The etiology was predominantly postsurgical (84.8%). 87.4% of patients received standard medication (oral calcium/vitamin D), 15 patients (7.6%) used rhPTH1-84/Natpar and 10 patients (4.5%) had no/unknown medication. 219 ER visits and 627 hospitalizations were documented among 149 patients, 49 patients (24.7%) did not record any hospital admissions. According to symptoms and decreased calcium levels, 12% of ER (n = 26) visits and 7% of hospitalizations (n = 44) were likely attributable to HP. A subgroup of 13 patients (6.5%) received kidney transplants prior to the HP diagnosis. In 8 of these patients, parathyroidectomy for tertiary renal hyperparathyroidism was the cause of permanent HP. The mortality was 7.8% (n = 12) and the causes of death appeared to be unrelated to HP. Although, the awareness for HP was low, calcium levels were documented in 71% (n = 447) of hospitalizations.
Conclusions: Acute symptoms directly related to HP did not represent the primary cause of ER visits. However, comorbidities (e.g. renal/cardiovascular diseases) associated with HP played a key role in hospitalizations and deaths.
Die 29-jährige Frau J. stellt sich im Rahmen einer Kontrolluntersuchung vor. Sie wurde aufgrund eines therapieresistenten Morbus Basedow und eines Knotens in der Schilddrüse im November 2017 thyreoidektomiert, abgesehen von einem BMI von 45 ist sie gesund. In der Knochendichtemessung mittels DXA imAbb. 1 8 a DXA-Bericht von Frau J. mit deutlich erhöhten T-und Z-Werten April 2021 zeigen sich überdurchschnittlich hohe Werte (. Abb. 1). Welche Ursache könnte die hohe Knochendichte haben? a) Die Patientin hat an einer klinischen Studie mit Romosozumab teilgenommen. b) Familiäres Osteopetrose-Syndrom c) Postoperativer Hypoparathyreoidismus d) Myelofibrose e) Morbus Paget
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