The cellular immune response of 8 patients from the Brazilian Amazon region with chromoblastomycosis was analyzed. Primary immunological responses of patients were tested by contact sensitization to 2,4-dinitro-chlorobenzene (DNCB), or rejection of first set skin allografts. 2 of 8 patients were reactive to DNCB after sensitization, and skin allograft rejection occurred in an average of 14 days. Capacity of patients to mount recall immunological responses was measured by skin testing with two fungal antigens and three bacterial antigens. Delayed skin reaction to trichophytin and candida antigens was negative in the majority of the patients. However, reactivity to mycobacterial (tuberculin), and bacterial (staphylococcal, streptococcal) antigen was high, or only slightly diminished respectively. The data suggest that patients with chromoblastomycosis have suppressed nonspecific, cell mediated immunity for some antigens (skin allografts, DNCB, fungal antigens), while reactivity to bacterial and mycobacterial antigens is not impaired.
SINOPSEOs autores descrevem um caso de Tinea Nigra localizado sobre um hsmangicma plano, na palma da mão direita de uma paciente que tinha, concomitantemente, Estrófula alimentar. Embora não seja essa a primeira observação dessa dermatose no Estado do Amazonas, esse é, no entanto, o primeiro caso descrito, com a identificação sistemática do agente etiológico. O fungo isolado no meio de Sabouraud-dextroseagar, é classificado pelos Autores como Pullularia wernecki (Horta) de Vries.
REGISTRO DO CASO
Sinopse Um caso de blastomicose sul-americana em Manaus A observação micológica inicialmente usada foi o exame direto da secreção que acusou presença de células características do microrganismo. Cultura no meio padrão Sabouraud-dextrose-agar contendo antibióticos nas concentrações: cloranfenicol 50 mg./1.000 ml. de meio e ciclohexemida 250 mg/1.000 ml. de meio. Após 21 dias, evidência do Paracoccidioides brasiliensis de aspecto cotonoso. Tratamento com Fanasulf (Sulfadoxina) dois comprimidos (500 mg. cada) por semana, respondendo satisfatoriamente à droga. Depois de oito meses de medicação, o paciente recebeu alta, apresentando-se totalmente curado.
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