Abstract-Both branch-line and rat-race couplers are easily realized using planar circuit technology as they employ only transmission lines without additional components. However, as the electrical lengths of the transmission line elements are either 90 or 270 , such couplers consume a significant amount of circuit area. This paper shows the development of branch-line and rat-race couplers that use artificial transmission lines (ATLs) in place of conventional transmission lines resulting in significant size reduction. As the ATLs are constructed entirely from microstriplines, the couplers are easily fabricated using conventional printed-circuit processes. The design formulas developed for the ATLs are explicit. Full-wave simulation and experimental results were used to confirm the design approach for hybrids operating at 1.8 GHz. The frequency response of the proposed hybrids is similar to conventional hybrids.

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The Maslach Burnout Inventory for healthcare professionals (MBI-HSS) and its abbreviated version (aMBI), are the most common tools to detect burnout in clinicians. A wide range in burnout prevalence is reported in anesthesiology, so this study aimed to ascertain which of these two tools most accurately detected burnout in our anesthesiology residents. The MBI-HSS and aMBI were distributed amongst 86 residents across three hospitals, with a total of 58 residents completing the survey (67.4% response rate; 17 male and 41 female). Maslach-recommended cut-offs for the MBI-HSS and the aMBI with standard cut-offs were used to estimate burnout prevalence, and actual prevalence was established clinically by a thorough review of multiple data sources. Burnout proportions reported by the MBI-HSS and aMBI were found to be significantly different; 22.4% vs. 62.1% respectively (p < 0.0001). Compared to the actual prevalence of burnout in our cohort, the MBI-HSS detected burnout most accurately; area under receiver operating characteristic of 0.99 (95% confidence interval (CI): 0.92–1.0). Although there was a good correlation between the MBI-HSS and aMBI subscale scores, the positive predictive value of the aMBI was poor; 33.3% (95% CI:27.5–39.8%), therefore caution and clinical correlation are advised when using the aMBI tool because of the high rates of false-positives.

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Abstract-The optimal detection of signals requires detailed knowledge of the noise statistics. In many applications, the assumption of Gaussian noise allows the use of the linear correlator (LC), which is known to be optimal in these circumstances. However, the performance of the LC is poor in warm shallow waters where snapping shrimp noise dominates in the range 2-300 kHz. Since snapping shrimp noise consists of a large number of individual transients, its statistics are highly non-Gaussian. We show that the noise statistics can be described accurately by the symmetric -stable family of probability distributions. Maximum-likelihood (ML) and locally optimal detectors based on the detailed knowledge of the noise probability distribution are shown to demonstrate enhanced performance. We also establish that the sign correlator, which is a nonparametric detector, performs better than the LC in snapping shrimp noise. Although the performance of the sign correlator is slightly inferior to that of the ML detector, it is very simple to implement and does not require detailed knowledge of the noise statistics. This makes it an attractive compromise between the simple LC and the complex ML detector.

Human monocytes can be classified into two subsets with distinctive characteristics. In this study, we report a difference in apoptotic potential between these two subsets with CD14+/lowCD16+ monocytes being more susceptible than CD14+CD16− monocytes to undergo spontaneous apoptosis and apoptosis induced by reactive oxygen species (ROS). By global transcriptomic and proteomic approaches, we observed that CD14+/lowCD16+ monocytes expressed higher levels of pro-apoptotic genes and proteins such as TNFα, caspase 3, Bax and cytochrome c and showed more caspases 3 and 7 activities. They also exhibited greater aerobic respiration resulting in a higher production of ROS from the mitochondria. CD14+CD16− monocytes, in contrast, showed higher expression of glutathione (GSH)-metabolizing genes such as GSH peroxidase and microsomal GSH S-transferase and were more resistant to oxidative stress than CD14+/lowCD16+ monocytes. The apoptosis of CD14+/lowCD16+ monocytes was ROS dependent as reducing ROS levels significantly reduced cell death. This is the first report of a differential apoptotic propensity of human monocyte subsets, and gaining a better understanding of this process may help to provide a better understanding of the roles of these subsets during homeostasis and under pathological conditions, particularly in situations in which high levels of oxidants are present.

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