Bit configuration and acting rein forces play a crucial role in oral health and comfort of ridden horses. Although it is a big animal welfare issue, dynamic response of horses to different bits has yet not been thoroughly investigated. This convenience sample experimental study describes a model to overcome the almost uncontrollable influence of riders on rein tension and evaluates self-controlled maximum side rein tension of ten sound horses randomly bitted with a double-jointed (DJS) and a version of a Mullen mouth snaffle-bit under unridden conditions. Horses were exercised at walk and trot on a horizontal treadmill wearing custom made force-sensing resistors (FSR) equipped to side reins. FSR were synchronized with a camera-based motion analysis system providing information on amplitudes and temporal occurrence of self-controlled maximum side rein tensile forces during different phases of separated motion cycles. The DJS exhibited larger side rein tension, indicating higher bit contact. Constant temporal occurrence of monophasic maxima at walk and biphasic maxima at trot could be observed in both bits. Within the limitations of this study, application of FSR linked to side reins in unridden horses may provide a promising tool when studying subjective response of horses to different bits.
Extracellular vesicles (EVs), such as exosomes, microvesicles, and apoptotic bodies, are cell-derived, lipid bilayer-enclosed particles mediating intercellular communication and are therefore vital for transmitting a plethora of biological signals. The vascular endothelium substantially contributes to the circulating particulate secretome, targeting important signaling pathways that affect blood cells and regulate adaptation and plasticity of endothelial cells in a paracrine manner. Different molecular signatures and functional properties of endothelial cells reflect their heterogeneity among different vascular beds and drive current research to understand varying physiological and pathological effects of blood and lymphatic endothelial EVs. Endothelial EVs have been linked to the development and progression of various vascular diseases, thus having the potential to serve as biomarkers and clinical treatment targets. This review aims to provide a brief overview of the human vasculature, the biology of extracellular vesicles, and the current knowledge of endothelium-derived EVs, including their potential role as biomarkers in disease development.
The angle encompassed between opposing incisors in horses is assumed to decline with age. Previous studies merely consider the overall profile view of clinical crowns presuming a generalized angle, neglecting potential tooth position-dependent differences. Cephalometric measurements from 3D computed tomographic thick-slab reconstructions of single incisors within a global reference frame were used to determine clinical crown interincisal angulation (IIA) of 48 horses. Based on predefined dentoalveolar landmarks, IIA was defined as the angle enclosed by the respective labial axis of the clinical crown (LACC). A measurement repeatability analysis was conducted including a comparison of third incisor teeth IIA with data obtained by cephalometric implementation of previously described landmarks for third incisor teeth (lingual/palatal border). The age-related angle course and differences between tooth positions were investigated considering LACCs of permanent incisors. Determining IIA by LACCs exhibited a high level of reproducibility applying for all tooth positions (mean coefficient of variation = 0.65 %; mean SD ± 0.89°). The comparison method for third incisor teeth revealed two times higher mean dispersion of repeated measurements, P = 0.017. A non-linear model slightly increased predictability of angular changes over time as against linearity assumption. The angle decline was more distinctive in younger horses and appears to approach a final value in older ones. Third incisor teeth exhibited significantly higher angle decline compared to first and second incisor teeth, P < 0.0001. According to the results, age determination of horses using clinical crown IIA is not recommended. Rather, 3D cephalometry may provide a promising tool to determine interdental and dentofacial angles of distinct tooth positions in health and disease.
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