This work describes the synthesis and determination of the sun protection factor (SPF) of sunscreen formulations containing two chemical filters obtained from vanillin. The syntheses yield reached 85% and 60% for obtaining the derivative 1 (4-(4hydroxy-3-methoxyphenyl)-3-buten-2-one) and derivative 2 (4-(4-acetyloxy-3methoxyphenyl)-3-buten-2-one), respectively. Formulations containing the chemical filters synthesized, at a concentration of 5.0%(w/w), showed UVB SPF in vitro equal to: derivative 1 (8.5 ± 0.2) and derivative 2 (12.2 ± 0.9). These values were higher than the formulation containing benzophenone-3 (6.9 ± 0.6) at the same concentration.
RESUMOEstudos prospectivos representam forma profícua de gestão de saberes e tecnologias desenvolvidas em saúde, setor que objetiva o tratamento de indivíduos afetados por processos fisiopatológicos, como a dor musculoesquelética, cuja terapia pode envolver plantas medicinais, como o Zingiber officinale Roscoe. O presente artigo pretendeu a verificação do rizoma frente ao cenário de patentes e artigos abordando seu uso frente às condições musculoesqueléticas. Utilizaram-se diversos descritores, como "gengibre" e "dor musculoesquelética", que deveriam compor a seção "título" e ou resumo em bancos de patentes e artigos, seguido de triagem dos resultados. Dos bancos consultados, WIPO e Scopus apresentaram os maiores resultados para patentes e artigos respectivamente, com 99 e 17 resultados, figurando os Estados Unidos como maior depositário e país da maioria dos artigos. 78 patentes corresponderam à classificação A61K, não havendo correlação para número de artigos e patentes. O Brasil não apresentou resultados para patentes depositadas e artigos publicados.Palavras-chave: Prospecção. Zingiber officinale Roscoe. Dor musculoesquelética. TECHNOLOGICAL PROSPECTION OF ZINGIBER OFFICINALE ROSCOE (GINGER) RIZOMA USED IN THE TREATMENT OF MUSCULOSKELETIC PAIN ABSTRACTProspective studies represent fruitful form of management knowledge and health technologies developed sector that aims to treat individuals affected by pathophysiological processes such as musculoskeletal pain, which may involve medicinal plant therapy, such as Zingiber officinale Roscoe. This article is intended to check the rhizome against the backdrop of patents and articles addressing their front use the musculoskeletal conditions. We used different descriptors, such as "ginger" and "musculoskeletal pain", which should make up the "title" and or "abstract" sections in banks of patents and articles, followed by screening of results. WIPO and Scopus showed the highest results for patents and articles respectively, with 99 and 17 results, ranking the United States as the depositary and country of most articles. 78 patents corresponded to A61K classification, with no correlation to the number of articles and patents. Brazil does not show any results for patents or articles.
The use of sunscreen is one of the photoprotection measures most used by the population, so these products must offer broad-spectrum protection against UVA and UVB radiation. Encholirium spectabile, popularly known as "macambira-deflecha," is a species characterized by its rocky outcrops and found in the Caatinga. This biome is known for extreme droughts and dry periods, and for this reason, its vegetation needed to develop resistance mechanisms. The aim of this work was to evaluate the use of E. spectabile incorporated in O/W emulsion as a potential photoprotective agent and their antioxidant activity. Four chemical constituents (ferulic acid, caffeic acid, p-coumaric acid and apigenin) were identified by HPLC-DAD analysis, and emulsions containing different concentrations (1%, 2.5% and 5%) of the extract without and with the addition of chemical filters (octyl methoxycinnamate and benzophenone-3) were prepared and submitted to the test of preliminary stability. The Q formulation demonstrated little variation in the preliminary stability test and was selected for estimated your protection against UVB and determination of in vitro protection factor UVA. The formulations remained stable during the freeze-thaw cycle; the extract despite maintaining the UVA-PF and decreasing the wavelength showed an increase in FPS from 14.4 (control) to 18.8 (control+ Es-HA80).
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