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This paper reports the activity, promoted by the Italian agency for new technologies, energy and sustainable economic development (ENEA), in the framework of the project for the development and implementation of the first Italian Platform for Industrial Symbiosis implemented in Sicily (2011Sicily ( -2015. The goals of the project were: to provide a methodology and an instrument for industrial symbiosis implementation at regional scale, to implement a IS Platform as a support to SMEs to individuate symbiosis opportunities in the region. The whole approach includes: network activation, platform architecture design and implementation, analysis of the productive sector in Sicily, data collection and companies involvement. In particular the paper focuses on the activities developed for companies' network creation trough a preliminary analysis of the predominant productive sectors followed by the organization of operative meetings in Sicily for companies' involvement, analysis of potential synergies and resources sharing, and finally platform population. During the first two meetings more than 80 SME were linked giving rise to almost 400 output resources and almost 180 input resources. More than 690 potential matches were found between the participating enterprises showing interesting opportunities both for substituting resources with waste products in real and virtual cases and for sharing waste management services and infrastructures. The discussion occurred during the meeting has remarked the significance and the consequences of the regulatory and control system on IS application, underlining the necessary participation of local stakeholders and control authorities. It has also emerged the need to identify predominant productive activities in well-defined territorial contexts where to investigate the specific/local tangles taking into account legislative and technical-economic feasibility. Technical dossiers on three main resource streams (wastes from processing stone materials; plastics and agro-industrial wastes), which may generate the more interesting potential synergies, are being processed. These dossiers include European, Italian and regional regulations, guidelines, technical standards, logistic and economical aspects useful for supporting companies in synergies implementation. Results of this activity will also be used to improve the algorithm in the platform to find synergies.

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Methamphetamine (MET) is one of the most used illicit drugs in Europe and is recognized as one of the Emerging Organic Micropollutants. It is discharged into the sewerage system from different sources and then enters the wastewater treatment plants. The present study aimed at providing a better knowledge of the fate of MET through the wastewater treatment plants. The study addressed two different issues: (1) optimization of the analytical methods for MET determination in both liquid and sludge phases, focusing on the effects of potentially interfering substances and (2) investigation on the behaviour of MET in the biological treatment process, with specific concern for the biomass activity at different drug concentrations. Results of the study on issue 1 highlighted that the applied analytical method for MET determination (UPLC-MS/MS) is affected by the main components of wastewater for about 9-23%, which is comparable with the uncertainties of the method (about ± 28%). The method showed also to be repeatable and reliable (recovery > 75%; repeatability < 10-15%; bias uncertainty < 30%), and relatively easy-to-use. Therefore, it can be considered suitable for measurements on routine base in the WWTPs. Batch tests conducted to address issue 2 showed total removal of 84, 90, and 96% at 50, 100, and 200 ng/L initial MET concentration, respectively, for a contact time of 6 h. The removal process was mainly ascribed to the biological activity of both heterotrophic and autotrophic bacteria. The pseudo first-order kinetic model provided the best fitting of the experimental data of the overall biological processes at all the tested concentrations. Furthermore, the respirometric tests showed that MET does not induce any inhibition. Adsorption of MET on activated sludge was always very low.