Introduction Breast cancer is the most frequent malignant disease in women. Exposure to estrogens throughout a woman's life is a risk factor for the development of breast cancer. Organochlorine compounds (OCCs), such as pesticides and polychlorinated biphenyls, are persistent lipophilic chemicals identified as endocrine disruptors, mainly with estrogenic effects. To test the hypothesis that the amount and quality of organochlorine residues in adipose tissue adjacent to breast carcinoma affect the biological behavior of the tumor, we studied biomarker expression in breast carcinoma and the OCC body burden in patients from an urban area adjacent to Paraná fluvial system, Argentina.
1 ) are compatible with current worldwide regulations (maximum levels of 0.5 and 0.05 μg L −1 ). The procedure was applied to samples that were naturally contaminated with a range of AFM1 at LOQ-0.187 μg L −1 , with comparable results to IAC clean-up, which was employed as a reference method. Therefore, AFM1 determination in raw milk by UHPLC-MS/MS detection through the present QuEChERS extraction constitutes a reliable alternative to IAC clean-up and exhibits advantages related to cost, accessibility of materials and simplicity of operation.
Keywords LC-MS/MS • QuEChERS • Mycotoxins • Pesticides • MilkPublished in the topical collection 5th Latin American Pesticide Residue Workshop with guest editor Steven J. Lehotay.
We examined the bioaccumulation of α- and β-endosulfan and endosulfan sulfate in tissues from the crab Zilchiopsis collastinensis. There was more endosulfan accumulated in the hepatopancreas (from <2 to 467.8 ng g(-1)) than in the gonads (from <2 to 52.1 ng g(-1)) or muscles (<2 ng g(-1)). The endosulfan concentrations in the hepatopancreas decreased over time and with the endosulfan dilution (p < 0.05). In the gonads there was little bioaccumulation, which did not vary over time (p > 0.05). The hepatopancreas is a dynamic organ that is able to depurate itself, whereas the gonads act as a sink for pesticides.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.