1Normal human lymphocytes (L) (8 x lO0 ml-) incubated with methoxamine (Me) (1 x 10-7M) (Me-L) triggered the mchanical response of the isolated vas deferens of the rat. L or Me alone did not modify this contractile activity at the concentrations cited above. 2 Me alone (10 -6to 10 -3 M) increased the tension of the vas. In the presence of L (8 x 105 ml -1) the dose-response curve to Me shifted to the left and the efficacy of Me was enhanced.
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